                         SEQUENCE LISTING

<110>  COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
 
<120>  Protein fusion construct possesing thrombolytic and anticoagulant
        properties

<130>  LLS207

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARTIFICAILLY SYNTHESIZED

<400>  1
attgctggac ctgagtggct gctagaccgt ccatctgtca acaacagcca attagttgtt       60

agcgttgctg gtactgttga ggggacgaat caagacatta gtcttaaatt ttttgaaatc      120

gatctaacat cacgacctgc tcatggagga aagacagagc aaggcttaag tccaaaatca      180

aaaccatttg ctactgatag tggcgcgatg tcacataaac ttgagaaagc tgacttacta      240

aaggctattc aagaacaatt gatcgctaac gtccacagta acgacgacta ctttgaggtc      300

attgattttg caagcgatgc aaccattact gatcgaaacg gcaaggtcta ctttgctgac      360

aaagatggtt cggtaacctt gccgacccaa cctgtccaag aatttttgct aagcggacat      420

gtgcgcgtta gaccatataa agaaaaacca atacaaaacc aagcgaaatc tgttgatgtg      480

gaatatactg tacagtttac tcccttaaac cctgatgacg atttcagacc aggtctcaaa      540

gatactaagc tattgaaaac actagctatc ggtgacacca tcacatctca agaattacta      600

gctcaagcac aaagcatttt aaacaaaaac cacccaggct atacgattta tgaacgtgac      660

tcctcaatcg tcactcatga caatgacatt ttccgtacga ttttaccaat ggatcaagag      720

tttacttacc gtgttaaaaa tcgggaacaa gcttatagga tcaataaaaa atctggtctg      780

aatgaagaaa taaacaacac tgacctgatc tctgagaaat attacgtcct taaaaaaggg      840

gaaaagccgt atgatccctt tgatcgcagt cacttgaaac tgttcaccat caaatacgtt      900

gatgtcgata ccaacgaatt gctaaaaagt gagcagctct taacagctag cgaacgtaac      960

ttagacttca gagatttata cgatcctcgt gataaggcta aactactcta caacaatctc     1020

gatgcttttg gtattatgga ctatacctta actggaaaag tagaggataa tcacgatgac     1080

accaaccgta tcataaccgt ttatatgggc aagcgacccg aaggagagaa tgctagctat     1140

catttagcct atgataaaga tcgttatacc gaagaagaac gagaagttta cagctacctg     1200

cgttatacag ggacacctat acctgataac cctaacgaca aataa                     1245


<210>  2
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARTIFICIALLY SYNTHESIZED

<400>  2
gtggacccgt gcttcagagc caactgcgag taccagtgcc agcccctgaa ccaaactagc       60

tacctctgcg tctgcgccga gggcttcgcg cccattcccc acgagccgca caggtgccag      120

atgttttgca accagactgc ctgtccagcc gactgcgacc ccaacaccca ggctagctgt      180

gagtgccctg aaggctacat cctggacgac ggtttcatct gcacggacat cgacgagtgc      240

gaaaacggcg gcttctgctc cggggtgtgc cacaacctcc ccggtacctt cgagtgcatc      300

tgcgggcccg actcggccct tgcccgccac attggcaccg actgtgactc cggc            354


<210>  3
<211>  1605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificail made fusion construct

<400>  3
attgctggac ctgagtggct gctagaccgt ccatctgtca acaacagcca attagttgtt       60

agcgttgctg gtactgttga ggggacgaat caagacatta gtcttaaatt ttttgaaatc      120

gatctaacat cacgacctgc tcatggagga aagacagagc aaggcttaag tccaaaatca      180

aaaccatttg ctactgatag tggcgcgatg tcacataaac ttgagaaagc tgacttacta      240

aaggctattc aagaacaatt gatcgctaac gtccacagta acgacgacta ctttgaggtc      300

attgattttg caagcgatgc aaccattact gatcgaaacg gcaaggtcta ctttgctgac      360

aaagatggtt cggtaacctt gccgacccaa cctgtccaag aatttttgct aagcggacat      420

gtgcgcgtta gaccatataa agaaaaacca atacaaaacc aagcgaaatc tgagcccgtg      480

gacccgtgct tcagagccaa ctgcgagtac cagtgccagc ccctgaacca aactagctac      540

ctctgcgtct gcgccgaggg cttcgcgccc attccccacg agccgcacag gtgccagatg      600

ttttgcaacc agactgcctg tccagccgac tgcgacccca acacccaggc tagctgtgag      660

tgccctgaag gctacatcct ggacgacggt ttcatctgca cggacatcga cgagtgcgaa      720

aacggcggct tctgctccgg ggtgtgccac aacctccccg gtaccttcga gtgcatctgc      780

gggcccgact cggcccttgc ccgccacatt ggcactgact gtgactccgg cgttgatgtg      840

gaatatactg tacagtttac tcccttaaac cctgatgacg atttcagacc aggtctcaaa      900

gatactaagc tattgaaaac actagctatc ggtgacacca tcacatctca agaattacta      960

gctcaagcac aaagcatttt aaacaaaaac cacccaggct atacgattta tgaacgtgac     1020

tcctcaatcg tcactcatga caatgacatt ttccgtacga ttttaccaat ggatcaagag     1080

tttacttacc gtgttaaaaa tcgggaacaa gcttatagga tcaataaaaa atctggtctg     1140

aatgaagaaa taaacaacac tgacctgatc tctgagaaat attacgtcct taaaaaaggg     1200

gaaaagccgt atgatccctt tgatcgcagt cacttgaaac tgttcaccat caaatacgtt     1260

gatgtcgata ccaacgaatt gctaaaaagt gagcagctct taacagctag cgaacgtaac     1320

ttagacttca gagatttata cgatcctcgt gataaggcta aactactcta caacaatctc     1380

gatgcttttg gtattatgga ctatacctta actggaaaag tagaggataa tcacgatgac     1440

accaaccgta tcataaccgt ttatatgggc aagcgacccg aaggagagaa tgctagctat     1500

catttagcct atgataaaga tcgttatacc gaagaagaac gagaagttta cagctacctg     1560

cgttatacag ggacacctat acctgataac cctaacgaca aataa                     1605


<210>  4
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  custom made fusion gene

<400>  4
gtggacccgt gcttcagagc caactgcgag taccagtgcc agcccctgaa ccaaactagc       60

tacctctgcg tctgcgccga gggcttcgcg cccattcccc acgagccgca caggtgccag      120

atgttttgca accagactgc ctgtccagcc gactgcgacc ccaacaccca ggctagctgt      180

gagtgccctg aaggctacat cctggacgac ggtttcatct gcacggacat cgacgagtgc      240

gaaaacggcg gcttctgctc cggggtgtgc cacaacctcc ccggtacctt cgagtgcatc      300

tgcgggcccg actcggccct tgcccgccac attggcaccg actgtgactc cggcattgct      360

ggacctgagt ggctgctaga ccgtccatct gtcaacaaca gccaattagt tgttagcgtt      420

gctggtactg ttgaggggac gaatcaagac attagtctta aattttttga aatcgatcta      480

acatcacgac ctgctcatgg aggaaagaca gagcaaggct taagtccaaa atcaaaacca      540

tttgctactg atagtggcgc gatgtcacat aaacttgaga aagctgactt actaaaggct      600

attcaagaac aattgatcgc taacgtccac agtaacgacg actactttga ggtcattgat      660

tttgcaagcg atgcaaccat tactgatcga aacggcaagg tctactttgc tgacaaagat      720

ggttcggtaa ccttgccgac ccaacctgtc caagaatttt tgctaagcgg acatgtgcgc      780

gttagaccat ataaagaaaa accaatacaa aaccaagcga aatctgttga tgtggaatat      840

actgtacagt ttactccctt aaaccctgat gacgatttca gaccaggtct caaagatact      900

aagctattga aaacactagc tatcggtgac accatcacat ctcaagaatt actagctcaa      960

gcacaaagca ttttaaacaa aaaccaccca ggctatacga tttatgaacg tgactcctca     1020

atcgtcactc atgacaatga cattttccgt acgattttac caatggatca agagtttact     1080

taccgtgtta aaaatcggga acaagcttat aggatcaata aaaaatctgg tctgaatgaa     1140

gaaataaaca acactgacct gatctctgag aaatattacg tccttaaaaa aggggaaaag     1200

ccgtatgatc cctttgatcg cagtcacttg aaactgttca ccatcaaata cgttgatgtc     1260

gataccaacg aattgctaaa aagtgagcag ctcttaacag ctagcgaacg taacttagac     1320

ttcagagatt tatacgatcc tcgtgataag gctaaactac tctacaacaa tctcgatgct     1380

tttggtatta tggactatac cttaactgga aaagtagagg ataatcacga tgacaccaac     1440

cgtatcataa ccgtttatat gggcaagcga cccgaaggag agaatgctag ctatcattta     1500

gcctatgata aagatcgtta taccgaagaa gaacgagaag tttacagcta cctgcgttat     1560

acagggacac ctatacctga taaccctaac gacaaataa                            1599


<210>  5
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOM MADE FUSION CONSTRUCT

<400>  5
attgctggac ctgagtggct gctagaccgt ccatctgtca acaacagcca attagttgtt       60

agcgttgctg gtactgttga ggggacgaat caagacatta gtcttaaatt ttttgaaatc      120

gatctaacat cacgacctgc tcatggagga aagacagagc aaggcttaag tccaaaatca      180

aaaccatttg ctactgatag tggcgcgatg tcacataaac ttgagaaagc tgacttacta      240

aaggctattc aagaacaatt gatcgctaac gtccacagta acgacgacta ctttgaggtc      300

attgattttg caagcgatgc aaccattact gatcgaaacg gcaaggtcta ctttgctgac      360

aaagatggtt cggtaacctt gccgacccaa cctgtccaag aatttttgct aagcggacat      420

gtgcgcgtta gaccatataa agaaaaacca atacaaaacc aagcgaaatc tgttgatgtg      480

gaatatactg tacagtttac tcccttaaac cctgatgacg atttcagacc aggtctcaaa      540

gatactaagc tattgaaaac actagctatc ggtgacacca tcacatctca agaattacta      600

gctcaagcac aaagcatttt aaacaaaaac cacccaggct atacgattta tgaacgtgac      660

tcctcaatcg tcactcatga caatgacatt ttccgtacga ttttaccaat ggatcaagag      720

tttacttacc gtgttaaaaa tcgggaacaa gcttatagga tcaataaaaa atctggtctg      780

aatgaagaaa taaacaacac tgacctgatc tctgagaaat attacgtcct taaaaaaggg      840

gaaaagccgt atgatccctt tgatcgcagt cacttgaaac tgttcaccat caaatacgtt      900

gatgtcgata ccaacgaatt gctaaaaagt gagcagctct taacagctag cgaacgtaac      960

ttagacttca gagatttata cgatcctcgt gataaggcta aactactcta caacaatctc     1020

gatgcttttg gtattatgga ctatacctta actggaaaag tagaggataa tcacgatgac     1080

accaaccgta tcataaccgt ttatatgggc aagcgacccg aaggagagaa tgctagctat     1140

catttagcct atgataaaga tcgttatacc gaagaagaac gagaagttta cagctacctg     1200

cgttatacag ggacacctat acctgataac cctaacgaca aataa                     1245


<210>  6
<211>  1530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOM MADE FUSION CONSTRUC

<400>  6
attgctggac ctgagtggct gctagaccgt ccatctgtca acaacagcca attagttgtt       60

agcgttgctg gtactgttga ggggacgaat caagacatta gtcttaaatt ttttgaaatc      120

gatctaacat cacgacctgc tcatggagga aagacagagc aaggcttaag tccaaaatca      180

aaaccatttg ctactgatag tggcgcgatg tcacataaac ttgagaaagc tgacttacta      240

aaggctattc aagaacaatt gatcgctaac gtccacagta acgacgacta ctttgaggtc      300

attgattttg caagcgatgc aaccattact gatcgaaacg gcaaggtcta ctttgctgac      360

aaagatggtt cggtaacctt gccgacccaa cctgtccaag aatttttgct aagcggacat      420

gtgcgcgtta gaccatataa agaaaaacca atacaaaacc aagcgaaatc tgttgatgtg      480

gaatatactg tacagtttac tcccttaaac cctgatgacg atttcagacc aggtctcaaa      540

gatactaagc tattgaaaac actagctatc ggtgacacca tcacatctca agaattacta      600

gctcaagcac aaagcatttt aaacaaaaac cacccaggct atacgattta tgaacgtgac      660

tcctcaatcg tcactcatga caatgacatt ttccgtacga ttttaccaat ggatcaagag      720

tttacttacc gtgttaaaaa tcgggaacaa gcttatagga tcaataaaaa atctggtctg      780

aatgaagaaa taaacaacac tgacctgatc tctgagaaat attacgtcct taaaaaaggg      840

gaaaagccgt atgatccctt tgatcgcagt cacttgaaac tgttcaccat caaatacgtt      900

gatgtcgata ccaacgaatt gctaaaaagt gagcagctct taacagctag cgaacgtaac      960

ttagacttca gagatttata cgatcctcgt gataaggcta aactactcta caacaatctc     1020

gatgcttttg gtattatgga ctatacctta actggaaaag tagaggataa tcacgatgac     1080

accaaccgta tcataaccgt ttatatgggc aagcgacccg aaggagagaa tgctagctat     1140

catttagccg gtggcggaca agctcaacaa attgtggtgg acccgtgctt cagagccaac     1200

tgcgagtacc agtgccagcc cctgaaccaa actagctacc tctgcgtctg cgccgagggc     1260

ttcgcgccca ttccccacga gccgcacagg tgccagatgt tttgcaacca gactgcctgt     1320

ccagccgact gcgaccccaa cacccaggct agctgtgagt gccctgaagg ctacatcctg     1380

gacgacggtt tcatctgcac ggacatcgac gagtgcgaaa acggcggctt ctgctccggg     1440

gtgtgccaca acctccccgg taccttcgag tgcatctgcg ggcccgactc ggcccttgcc     1500

cgccacattg gcaccgactg tgactccggc                                      1530


<210>  7
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT

<400>  7
gtggacccgt gcttcagagc caactgcgag taccagtgcc agcccctgaa ccaaactagc       60

tacctctgcg tctgcgccga gggcttcgcg cccattcccc acgagccgca caggtgccag      120

atgttttgca accagactgc ctgtccagcc gactgcgacc ccaacaccca ggctagctgt      180

gagtgccctg aaggctacat cctggacgac ggtttcatct gcacggacat cgacgagtgc      240

gaaaacggcg gcttctgctc cggggtgtgc cacaacctcc ccggtacctt cgagtgcatc      300

tgcgggcccg actcggccct tgcccgccac attggcaccg actgtgactc cggcattgct      360

ggacctgagt ggctgctaga ccgtccatct gtcaacaaca gccaattagt tgttagcgtt      420

gctggtactg ttgaggggac gaatcaagac attagtctta aattttttga aatcgatcta      480

acatcacgac ctgctcatgg aggaaagaca gagcaaggct taagtccaaa atcaaaacca      540

tttgctactg atagtggcgc gatgtcacat aaacttgaga aagctgactt actaaaggct      600

attcaagaac aattgatcgc taacgtccac agtaacgacg actactttga ggtcattgat      660

tttgcaagcg atgcaaccat tactgatcga aacggcaagg tctactttgc tgacaaagat      720

ggttcggtaa ccttgccgac ccaacctgtc caagaatttt tgctaagcgg acatgtgcgc      780

gttagaccat ataaagaaaa accaatacaa aaccaagcga aatctgttga tgtggaatat      840

actgtacagt ttactccctt aaaccctgat gacgatttca gaccaggtct caaagatact      900

aagctattga aaacactagc tatcggtgac accatcacat ctcaagaatt actagctcaa      960

gcacaaagca ttttaaacaa aaaccaccca ggctatacga tttatgaacg tgactcctca     1020

atcgtcactc atgacaatga cattttccgt acgattttac caatggatca agagtttact     1080

taccgtgtta aaaatcggga acaagcttat aggatcaata aaaaatctgg tctgaatgaa     1140

gaaataaaca acactgacct gatctctgag aaatattacg tccttaaaaa aggggaaaag     1200

ccgtatgatc cctttgatcg cagtcacttg aaactgttca ccatcaaata cgttgatgtc     1260

gataccaacg aattgctaaa aagtgagcag ctcttaacag ctagcgaacg taacttagac     1320

ttcagagatt tatacgatcc tcgtgataag gctaaactac tctacaacaa tctcgatgct     1380

tttggtatta tggactatac cttaactgga aaagtagagg ataatcacga tgacaccaac     1440

cgtatcataa ccgtttatat gggcaagcga cccgaaggag agaatgctag ctatcattta     1500

gccggtggcg gacaagctca acaaattgtg gtggacccgt gcttcagagc caactgcgag     1560

taccagtgcc agcccctgaa ccaaactagc tacctctgcg tctgcgccga gggcttcgcg     1620

cccattcccc acgagccgca caggtgccag atgttttgca accagactgc ctgtccagcc     1680

gactgcgacc ccaacaccca ggctagctgt gagtgccctg aaggctacat cctggacgac     1740

ggtttcatct gcacggacat cgacgagtgc gaaaacggcg gcttctgctc cggggtgtgc     1800

cacaacctcc ccggtacctt cgagtgcatc tgcgggcccg actcggccct tgcccgccac     1860

attggcaccg actgtgactc cggc                                            1884


<210>  8
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE SYNTHESIZED

<400>  8
gttgaccctt gctttagagc caactgtgaa taccaatgcc agcctttgaa ccagacctca       60

tacttgtgtg tttgtgccga gggttttgca ccaattcctc atgaaccaca cagatgtcaa      120

atgttctgca accagactgc ctgtccagca gactgcgatc ctaatacaca agcttcttgt      180

gagtgccctg aaggatacat cttggatgac ggttttattt gtactgacat cgatgagtgc      240

gaaaacggtg gattttgtag tggtgtttgc cataatcttc caggaacctt cgaatgtatt      300

tgcggtcctg actctgcctt ggcaagacac atcggaactg actgtgattc cgga            354


<210>  9
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT

<400>  9
caagagattc atgctagatt cagaagaggt gctagatcct accaggtcat ttgtagagat       60

gaaaagacac aaatgatcta tcaacagcac cagtcatggc ttagacctgt tttgagaagt      120

aacagagtcg agtactgttg gtgcaattct ggtagagccc aatgtcatag tgttccagtc      180

aaatcatgta gtgaacctag atgctttaac ggtggaactt gtcaacaggc tttgtacttc      240

tctgatttcg tttgtcaatg cccagaggga ttcgctggta aatgttgcga aattgacacc      300

agagctactt gttacgaaga tcagggaatc tcatatagag gtacatggtc taccgctgag      360

tccggagccg aatgtactaa ctggaattct tccgctttgg cccaaaaacc atactctggt      420

agaagacctg atgctattag acttggtttg ggaaaccaca attattgcag aaatccagac      480

agagattcta agccttggtg ttacgttttt aaggccggaa aatattcaag tgaattctgt      540

tccacccctg catgctcaga gggtaacagt gattgttact ttggtaatgg atctgcttat      600

agaggaaccc attccttgac tgagtcaggt gccagttgtc ttccatggaa ctcaatgatt      660

ttgatcggaa aagtttacac tgcacaaaat cctagtgcac aggctcttgg tttgggaaag      720

cataactact gtagaaatcc agacggagat gccaaacctt ggtgtcacgt tcttaagaac      780

agaagattga catgggaata ctgtgacgtc ccatcttgtt ccacctgcgg tttgagacaa      840

tactcacaac ctcagtttag aattaaaggt ggattgttcg ctgatatcgc ctctcatcca      900

tggcaggctg ccatttttgc taagcacaga agatcccctg gagagagatt cctttgtggt      960

ggaattttga tctcttcctg ctggattttg tccgcagctc actgttttca agaaagattc     1020

ccacctcatc accttacagt tatcttggga agaacctaca gagttgtccc aggtgaagag     1080

gaacagaagt ttgaggttga aaaatacatt gtccataagg agttcgatga cgatacttat     1140

gacaatgata tcgcactttt gcaattgaag tctgattcaa gtagatgtgc tcaggaatct     1200

tccgttgtca gaactgtttg tttgccacct gctgaccttc aattgcctga ttggacagag     1260

tgtgaacttt ctggttacgg aaaacacgaa gccttgtctc cattttattc cgagagactt     1320

aaggaagcac atgttagatt gtatccttca agtagatgta catcccaaca ccttttgaac     1380

agaactgtca cagacaatat gttgtgtgct ggagatacca gatcaggtgg accacaagcc     1440

aacttgcatg acgcatgcca gggagatagt ggtggacctc ttgtttgttt gaatgacggt     1500

agaatgactc ttgtcggaat tatctcttgg ggtttgggat gtggtcaaaa agatgttcca     1560

ggtgtctaca ctaaggttac aaactatttg gactggatca gagataacat gagacca        1617


<210>  10
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT

<400>  10
gtcgatccat gttttagagc taattgcgag tatcaatgcc agcctcttaa ccaaacttct       60

tatttgtgtg tttgcgcaga gggttttgct cctatcccac acgagcctca tagatgccag      120

atgttttgca accagaccgc atgtccagct gactgcgatc ctaatactca agcttcctgt      180

gagtgccctg aaggttacat tttggacgat ggattcattt gcaccgatat tgacgaatgt      240

gagaacggtg gattttgttc aggagtttgc cacaatttgc caggtacatt cgaatgtatt      300

tgtggacctg atagtgctct tgccagacat attggaacag attgtgactc cggtcaagag      360

attcatgcta gattcagaag aggtgctaga tcctaccagg tcatttgtag agatgaaaag      420

acacaaatga tctatcaaca gcaccagtca tggcttagac ctgttttgag aagtaacaga      480

gtcgagtact gttggtgcaa ttctggtaga gcccaatgtc atagtgttcc agtcaaatca      540

tgtagtgaac ctagatgctt taacggtgga acttgtcaac aggctttgta cttctctgat      600

ttcgtttgtc aatgcccaga gggattcgct ggtaaatgtt gcgaaattga caccagagct      660

acttgttacg aagatcaggg aatctcatat agaggtacat ggtctaccgc tgagtccgga      720

gccgaatgta ctaactggaa ttcttccgct ttggcccaaa aaccatactc tggtagaaga      780

cctgatgcta ttagacttgg tttgggaaac cacaattatt gcagaaatcc agacagagat      840

tctaagcctt ggtgttacgt ttttaaggcc ggaaaatatt caagtgaatt ctgttccacc      900

cctgcatgct cagagggtaa cagtgattgt tactttggta atggatctgc ttatagagga      960

acccattcct tgactgagtc aggtgccagt tgtcttccat ggaactcaat gattttgatc     1020

ggaaaagttt acactgcaca aaatcctagt gcacaggctc ttggtttggg aaagcataac     1080

tactgtagaa atccagacgg agatgccaaa ccttggtgtc acgttcttaa gaacagaaga     1140

ttgacatggg aatactgtga cgtcccatct tgttccacct gcggtttgag acaatactca     1200

caacctcagt ttagaattaa aggtggattg ttcgctgata tcgcctctca tccatggcag     1260

gctgccattt ttgctaagca cagaagatcc cctggagaga gattcctttg tggtggaatt     1320

ttgatctctt cctgctggat tttgtccgca gctcactgtt ttcaagaaag attcccacct     1380

catcacctta cagttatctt gggaagaacc tacagagttg tcccaggtga agaggaacag     1440

aagtttgagg ttgaaaaata cattgtccat aaggagttcg atgacgatac ttatgacaat     1500

gatatcgcac ttttgcaatt gaagtctgat tcaagtagat gtgctcagga atcttccgtt     1560

gtcagaactg tttgtttgcc acctgctgac cttcaattgc ctgattggac agagtgtgaa     1620

ctttctggtt acggaaaaca cgaagccttg tctccatttt attccgagag acttaaggaa     1680

gcacatgtta gattgtatcc ttcaagtaga tgtacatccc aacacctttt gaacagaact     1740

gtcacagaca atatgttgtg tgctggagat accagatcag gtggaccaca agccaacttg     1800

catgacgcat gccagggaga tagtggtgga cctcttgttt gtttgaatga cggtagaatg     1860

actcttgtcg gaattatctc ttggggtttg ggatgtggtc aaaaagatgt tccaggtgtc     1920

tacactaagg ttacaaacta tttggactgg atcagagata acatgagacc agtcgatcca     1980

tgttttagag ctaattgcga gtatcaatgc cagcctctta accaaacttc ttatttgtgt     2040

gtttgcgcag agggttttgc tcctatccca cacgagcctc atagatgcca gatgttttgc     2100

aaccagaccg catgtccagc tgactgcgat cctaatactc aagcttcctg tgagtgccct     2160

gaaggttaca ttttggacga tggattcatt tgcaccgata ttgacgaatg tgagaacggt     2220

ggattttgtt caggagtttg ccacaatttg ccaggtacat tcgaatgtat ttgtggacct     2280

gatagtgctc ttgccagaca tattggaaca gattgtgact ccggt                     2325


<210>  11
<211>  1971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT

<400>  11
gtcgatccat gttttagagc taattgcgag tatcaatgcc agcctcttaa ccaaacttct       60

tatttgtgtg tttgcgcaga gggttttgct cctatcccac acgagcctca tagatgccag      120

atgttttgca accagaccgc atgtccagct gactgcgatc ctaatactca agcttcctgt      180

gagtgccctg aaggttacat tttggacgat ggattcattt gcaccgatat tgacgaatgt      240

gagaacggtg gattttgttc aggagtttgc cacaatttgc caggtacatt cgaatgtatt      300

tgtggacctg atagtgctct tgccagacat attggaacag attgtgactc cggtcaagag      360

attcatgcta gattcagaag aggtgctaga tcctaccagg tcatttgtag agatgaaaag      420

acacaaatga tctatcaaca gcaccagtca tggcttagac ctgttttgag aagtaacaga      480

gtcgagtact gttggtgcaa ttctggtaga gcccaatgtc atagtgttcc agtcaaatca      540

tgtagtgaac ctagatgctt taacggtgga acttgtcaac aggctttgta cttctctgat      600

ttcgtttgtc aatgcccaga gggattcgct ggtaaatgtt gcgaaattga caccagagct      660

acttgttacg aagatcaggg aatctcatat agaggtacat ggtctaccgc tgagtccgga      720

gccgaatgta ctaactggaa ttcttccgct ttggcccaaa aaccatactc tggtagaaga      780

cctgatgcta ttagacttgg tttgggaaac cacaattatt gcagaaatcc agacagagat      840

tctaagcctt ggtgttacgt ttttaaggcc ggaaaatatt caagtgaatt ctgttccacc      900

cctgcatgct cagagggtaa cagtgattgt tactttggta atggatctgc ttatagagga      960

acccattcct tgactgagtc aggtgccagt tgtcttccat ggaactcaat gattttgatc     1020

ggaaaagttt acactgcaca aaatcctagt gcacaggctc ttggtttggg aaagcataac     1080

tactgtagaa atccagacgg agatgccaaa ccttggtgtc acgttcttaa gaacagaaga     1140

ttgacatggg aatactgtga cgtcccatct tgttccacct gcggtttgag acaatactca     1200

caacctcagt ttagaattaa aggtggattg ttcgctgata tcgcctctca tccatggcag     1260

gctgccattt ttgctaagca cagaagatcc cctggagaga gattcctttg tggtggaatt     1320

ttgatctctt cctgctggat tttgtccgca gctcactgtt ttcaagaaag attcccacct     1380

catcacctta cagttatctt gggaagaacc tacagagttg tcccaggtga agaggaacag     1440

aagtttgagg ttgaaaaata cattgtccat aaggagttcg atgacgatac ttatgacaat     1500

gatatcgcac ttttgcaatt gaagtctgat tcaagtagat gtgctcagga atcttccgtt     1560

gtcagaactg tttgtttgcc acctgctgac cttcaattgc ctgattggac agagtgtgaa     1620

ctttctggtt acggaaaaca cgaagccttg tctccatttt attccgagag acttaaggaa     1680

gcacatgtta gattgtatcc ttcaagtaga tgtacatccc aacacctttt gaacagaact     1740

gtcacagaca atatgttgtg tgctggagat accagatcag gtggaccaca agccaacttg     1800

catgacgcat gccagggaga tagtggtgga cctcttgttt gtttgaatga cggtagaatg     1860

actcttgtcg gaattatctc ttggggtttg ggatgtggtc aaaaagatgt tccaggtgtc     1920

tacactaagg ttacaaacta tttggactgg atcagagata acatgagacc a              1971


<210>  12
<211>  1971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT

<400>  12
caagagattc atgctagatt cagaagaggt gctagatcct accaggtcat ttgtagagat       60

gaaaagacac aaatgatcta tcaacagcac cagtcatggc ttagacctgt tttgagaagt      120

aacagagtcg agtactgttg gtgcaattct ggtagagccc aatgtcatag tgttccagtc      180

aaatcatgta gtgaacctag atgctttaac ggtggaactt gtcaacaggc tttgtacttc      240

tctgatttcg tttgtcaatg cccagaggga ttcgctggta aatgttgcga aattgacacc      300

agagctactt gttacgaaga tcagggaatc tcatatagag gtacatggtc taccgctgag      360

tccggagccg aatgtactaa ctggaattct tccgctttgg cccaaaaacc atactctggt      420

agaagacctg atgctattag acttggtttg ggaaaccaca attattgcag aaatccagac      480

agagattcta agccttggtg ttacgttttt aaggccggaa aatattcaag tgaattctgt      540

tccacccctg catgctcaga gggtaacagt gattgttact ttggtaatgg atctgcttat      600

agaggaaccc attccttgac tgagtcaggt gccagttgtc ttccatggaa ctcaatgatt      660

ttgatcggaa aagtttacac tgcacaaaat cctagtgcac aggctcttgg tttgggaaag      720

cataactact gtagaaatcc agacggagat gccaaacctt ggtgtcacgt tcttaagaac      780

agaagattga catgggaata ctgtgacgtc ccatcttgtt ccacctgcgg tttgagacaa      840

tactcacaac ctcagtttag aattaaaggt ggattgttcg ctgatatcgc ctctcatcca      900

tggcaggctg ccatttttgc taagcacaga agatcccctg gagagagatt cctttgtggt      960

ggaattttga tctcttcctg ctggattttg tccgcagctc actgttttca agaaagattc     1020

ccacctcatc accttacagt tatcttggga agaacctaca gagttgtccc aggtgaagag     1080

gaacagaagt ttgaggttga aaaatacatt gtccataagg agttcgatga cgatacttat     1140

gacaatgata tcgcactttt gcaattgaag tctgattcaa gtagatgtgc tcaggaatct     1200

tccgttgtca gaactgtttg tttgccacct gctgaccttc aattgcctga ttggacagag     1260

tgtgaacttt ctggttacgg aaaacacgaa gccttgtctc cattttattc cgagagactt     1320

aaggaagcac atgttagatt gtatccttca agtagatgta catcccaaca ccttttgaac     1380

agaactgtca cagacaatat gttgtgtgct ggagatacca gatcaggtgg accacaagcc     1440

aacttgcatg acgcatgcca gggagatagt ggtggacctc ttgtttgttt gaatgacggt     1500

agaatgactc ttgtcggaat tatctcttgg ggtttgggat gtggtcaaaa agatgttcca     1560

ggtgtctaca ctaaggttac aaactatttg gactggatca gagataacat gagaccagtc     1620

gatccatgtt ttagagctaa ttgcgagtat caatgccagc ctcttaacca aacttcttat     1680

ttgtgtgttt gcgcagaggg ttttgctcct atcccacacg agcctcatag atgccagatg     1740

ttttgcaacc agaccgcatg tccagctgac tgcgatccta atactcaagc ttcctgtgag     1800

tgccctgaag gttacatttt ggacgatgga ttcatttgca ccgatattga cgaatgtgag     1860

aacggtggat tttgttcagg agtttgccac aatttgccag gtacattcga atgtatttgt     1920

ggacctgata gtgctcttgc cagacatatt ggaacagatt gtgactccgg t              1971


<210>  13
<211>  1860
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT

<400>  13
caagagattc atgctagatt cagaagaggt gctagatcct accaggtcat ttgtagagat       60

gaaaagacac aaatgatcta tcaacagcac cagtcatggc ttagacctgt tttgagaagt      120

aacagagtcg agtactgttg gtgcaattct ggtagagccc aatgtcatag tgttccagtt      180

aaatcagttg acccttgctt tagagccaac tgtgaatacc aatgccagcc tttgaaccag      240

acctcatact tgtgtgtttg tgccgagggt tttgcaccaa ttcctcatga accacacaga      300

tgtcaaatgt tctgcaacca gactgcctgt ccagcagact gcgatcctaa tacacaagct      360

tcttgtgagt gccctgaagg atacatcttg gatgacggtt ttatttgtac tgacatcgat      420

gagtgcgaaa acggtggatt ttgtagtggt gtttgccata atcttccagg aaccttcgaa      480

tgtatttgcg gtcctgactc tgccttggca agacatatag gtactgactg tgattccgga      540

accagagcta cttgttacga agatcaggga atctcatata gaggtacatg gtctaccgct      600

gagtccggag ccgaatgtac taactggaat tcttccgctt tggcccaaaa accatactct      660

ggtagaagac ctgatgctat tagacttggt ttgggaaacc acaattattg cagaaatcca      720

gacagagatt ctaagccttg gtgttacgtt tttaaggccg gaaaatattc aagtgaattc      780

tgttccaccc ctgcatgctc agagggtaac agtgattgtt actttggtaa tggatctgct      840

tatagaggaa cccattcctt gactgagtca ggtgccagtt gtcttccatg gaactcaatg      900

attttgatcg gaaaagttta cactgcacaa aatcctagtg cacaggctct tggtttggga      960

aagcataact actgtagaaa tccagacgga gatgccaaac cttggtgtca cgttcttaag     1020

aacagaagat tgacatggga atactgtgac gtcccatctt gttccacctg cggtttgaga     1080

caatactcac aacctcagtt tagaattaaa ggtggattgt tcgctgatat cgcctctcat     1140

ccatggcagg ctgccatttt tgctaagcac agaagatccc ctggagagag attcctttgt     1200

ggtggaattt tgatctcttc ctgctggatt ttgtccgcag ctcactgttt tcaagaaaga     1260

ttcccacctc atcaccttac agttatcttg ggaagaacct acagagttgt cccaggtgaa     1320

gaggaacaga agtttgaggt tgaaaaatac attgtccata aggagttcga tgacgatact     1380

tatgacaatg atatcgcact tttgcaattg aagtctgatt caagtagatg tgctcaggaa     1440

tcttccgttg tcagaactgt ttgtttgcca cctgctgacc ttcaattgcc tgattggaca     1500

gagtgtgaac tttctggtta cggaaaacac gaagccttgt ctccatttta ttccgagaga     1560

cttaaggaag cacatgttag attgtatcct tcaagtagat gtacatccca acaccttttg     1620

aacagaactg tcacagacaa tatgttgtgt gctggagata ccagatcagg tggaccacaa     1680

gccaacttgc atgacgcatg ccagggagat agtggtggac ctcttgtttg tttgaatgac     1740

ggtagaatga ctcttgtcgg aattatctct tggggtttgg gatgtggtca aaaagatgtt     1800

ccaggtgtct acactaaggt tacaaactat ttggactgga tcagagataa catgagacca     1860


<210>  14
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT

<400>  14
caagagattc atgctagatt cagaagaggt gctagatcct accaggtcat ttgtagagat       60

gaaaagacac aaatgatcta tcaacagcac cagtcatggc ttagacctgt tttgagaagt      120

aacagagtcg agtactgttg gtgcaattct ggtagagccc aatgtcatag tgttccagtt      180

aaatcagttg acccttgctt tagagccaac tgtgaatacc aatgccagcc tttgaaccag      240

acctcatact tgtgtgtttg tgccgagggt tttgcaccaa ttcctcatga accacacaga      300

tgtcaaatgt tctgcaacca gactgcctgt ccagcagact gcgatcctaa tacacaagct      360

tcttgtgagt gccctgaagg atacatcttg gatgacggtt ttatttgtac tgacatcgat      420

gagtgcgaaa acggtggatt ttgtagtggt gtttgccata atcttccagg aaccttcgaa      480

tgtatttgcg gtcctgactc tgccttggca agacatattg gtactgattg tgattccgga      540

aacagtgatt gttactttgg taatggatct gcttatagag gaacccattc cttgactgag      600

tcaggtgcca gttgtcttcc atggaactca atgattttga tcggaaaagt ttacactgca      660

caaaatccta gtgcacaggc tcttggtttg ggaaagcata actactgtag aaatccagac      720

ggagatgcca aaccttggtg tcacgttctt aagaacagaa gattgacatg ggaatactgt      780

gacgtcccat cttgttccac ctgcggtttg agacaatact cacaacctca gtttagaatt      840

aaaggtggat tgttcgctga tatcgcctct catccatggc aggctgccat ttttgctaag      900

cacagaagat cccctggaga gagattcctt tgtggtggaa ttttgatctc ttcctgctgg      960

attttgtccg cagctcactg ttttcaagaa agattcccac ctcatcacct tacagttatc     1020

ttgggaagaa cctacagagt tgtcccaggt gaagaggaac agaagtttga ggttgaaaaa     1080

tacattgtcc ataaggagtt cgatgacgat acttatgaca atgatatcgc acttttgcaa     1140

ttgaagtctg attcaagtag atgtgctcag gaatcttccg ttgtcagaac tgtttgtttg     1200

ccacctgctg accttcaatt gcctgattgg acagagtgtg aactttctgg ttacggaaaa     1260

cacgaagcct tgtctccatt ttattccgag agacttaagg aagcacatgt tagattgtat     1320

ccttcaagta gatgtacatc ccaacacctt ttgaacagaa ctgtcacaga caatatgttg     1380

tgtgctggag ataccagatc aggtggacca caagccaact tgcatgacgc atgccaggga     1440

gatagtggtg gacctcttgt ttgtttgaat gacggtagaa tgactcttgt cggaattatc     1500

tcttggggtt tgggatgtgg tcaaaaagat gttccaggtg tctacactaa ggttacaaac     1560

tatttggact ggatcagaga taacatgaga cca                                  1593


<210>  15
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT

<400>  15
gttgaccctt gcttcagagc caactgtgaa taccaatgcc agcctttgaa ccagacctca       60

tacttgtgtg tttgtgccga gggttttgca ccaattcctc atgaaccaca cagatgtcaa      120

atgttctgca accagactgc ctgtccagca gactgcgatc ctaatacaca agcttcttgt      180

gagtgccctg aaggatacat cttggatgac ggttttattt gtactgacat cgatgagtgc      240

gaaaacggtg gattttgtag tggtgtttgc cataatcttc caggaacctt cgaatgtatt      300

tgcggtcctg actctgcctt ggcaagacac atcggaactg actgtgattc cggacaagag      360

attcatgcta gattcagaag aggtgctaga tcctaccagg tcatttgtag agatgaaaag      420

acacaaatga tctatcaaca gcaccagtca tggcttagac ctgttttgag aagtaacaga      480

gtcgagtact gttggtgcaa ttctggtaga gcccaatgtc atagtgttcc agtcaagtca      540

aatagtgatt gttactttgg taatggatct gcttatagag gaacccattc cttgactgag      600

tcaggtgcca gttgtcttcc atggaactca atgattttga tcggaaaagt ttacactgca      660

caaaatccta gtgcacaggc tcttggtttg ggaaagcata actactgtag aaatccagac      720

ggagatgcca aaccttggtg tcacgttctt aagaacagaa gattgacatg ggaatactgt      780

gacgtcccat cttgttccac ctgcggtttg agacaatact cacaacctca gtttagaatt      840

aaaggtggat tgttcgctga tatcgcctct catccatggc aggctgccat ttttgctaag      900

cacagaagat cccctggaga gagattcctt tgtggtggaa ttttgatctc ttcctgctgg      960

attttgtccg cagctcactg ttttcaagaa agattcccac ctcatcacct tacagttatc     1020

ttgggaagaa cctacagagt tgtcccaggt gaagaggaac agaagtttga ggttgaaaaa     1080

tacattgtcc ataaggagtt cgatgacgat acttatgaca atgatatcgc acttttgcaa     1140

ttgaagtctg attcaagtag atgtgctcag gaatcttccg ttgtcagaac tgtttgtttg     1200

ccacctgctg accttcaatt gcctgattgg acagagtgtg aactttctgg ttacggaaaa     1260

cacgaagcct tgtctccatt ttattccgag agacttaagg aagcacatgt tagattgtat     1320

ccttcaagta gatgtacatc ccaacacctt ttgaacagaa ctgtcacaga caatatgttg     1380

tgtgctggag ataccagatc aggtggacca caagccaact tgcatgacgc atgccaggga     1440

gatagtggtg gacctcttgt ttgtttgaat gacggtagaa tgactcttgt cggaattatc     1500

tcttggggtt tgggatgtgg tcaaaaagat gttccaggtg tctacactaa ggttacaaac     1560

tatttggact ggatcagaga taacatgaga cca                                  1593


<210>  16
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CUSTOME MADE FUSION CONSTRUCT


<220>
<221>  misc_feature
<222>  (1)..(1593)

<400>  16
caagagattc atgctagatt cagaagaggt gctagatcct accaggtcat ttgtagagat       60

gaaaagacac aaatgatcta tcaacagcac cagtcatggc ttagacctgt tttgagaagt      120

aacagagtcg agtactgttg gtgcaattct ggtagagccc aatgtcatag tgttccagtc      180

aagtcaaata gtgattgtta ctttggtaat ggatctgctt atagaggaac ccattccttg      240

actgagtcag gtgccagttg tcttccatgg aactcaatga ttttgatcgg aaaagtttac      300

actgcacaaa atcctagtgc acaggctctt ggtttgggaa agcataacta ctgtagaaat      360

ccagacggag atgccaaacc ttggtgtcac gttcttaaga acagaagatt gacatgggaa      420

tactgtgacg tcccatcttg ttccacctgc ggtttgagac aatactcaca acctcagttt      480

agaattaaag gtggattgtt cgctgatatc gcctctcatc catggcaggc tgccattttt      540

gctaagcaca gaagatcccc tggagagaga ttcctttgtg gtggaatttt gatctcttcc      600

tgctggattt tgtccgcagc tcactgtttt caagaaagat tcccacctca tcaccttaca      660

gttatcttgg gaagaaccta cagagttgtc ccaggtgaag aggaacagaa gtttgaggtt      720

gaaaaataca ttgtccataa ggagttcgat gacgatactt atgacaatga tatcgcactt      780

ttgcaattga agtctgattc aagtagatgt gctcaggaat cttccgttgt cagaactgtt      840

tgtttgccac ctgctgacct tcaattgcct gattggacag agtgtgaact ttctggttac      900

ggaaaacacg aagccttgtc tccattttat tccgagagac ttaaggaagc acatgttaga      960

ttgtatcctt caagtagatg tacatcccaa caccttttga acagaactgt cacagacaat     1020

atgttgtgtg ctggagatac cagatcaggt ggaccacaag ccaacttgca tgacgcatgc     1080

cagggagata gtggtggacc tcttgtttgt ttgaatgacg gtagaatgac tcttgtcgga     1140

attatctctt ggggtttggg atgtggtcaa aaagatgttc caggtgtcta cactaaggtt     1200

acaaactatt tggactggat cagagataac atgagaccag tcgatccatg ttttagagct     1260

aattgcgagt atcaatgcca gcctcttaac caaacttctt atttgtgtgt ttgcgcagag     1320

ggttttgctc ctatcccaca cgagcctcat agatgccaga tgttttgcaa ccagaccgca     1380

tgtccagctg actgcgatcc taatactcaa gcttcctgtg agtgccctga aggttacatt     1440

ttggacgatg gattcatttg caccgatatt gacgaatgtg agaacggtgg attttgttca     1500

ggagtttgcc acaatttgcc aggtacattc gaatgtattt gtggacctga tagtgctctt     1560

gccagacata ttggaacaga ttgtgactca ggt                                  1593


<210>  17
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARTIFICIALLY SYNTHESIZED

<400>  17
atgtcaagtt cattcgacaa aggaaaatat aaaaaaggcg atgacgcgag ttattttgaa       60

ccaacaggcc cgtatttgat ggtaaatgtg actggagttg atagtaaagg aaatgaattg      120

ctatcccctc attatgtcga gtttcctatt aaacctggga ctacacttac aaaagaaaaa      180

attgaatact atgtcgaatg ggcattagat gcgacagcat ataaagagtt tagagtagtt      240

gaattagatc caagcgcaaa gatcgaagtc acttattatg ataagaataa gaaaaaagaa      300

gaaacgaagt ctttccctat aacagaaaaa ggttttgttg tcccagattt atcagagcat      360

attaaaaacc ctggattcaa cttaattaca aaggttgtta tagaaaagaa ataa            414


<210>  18
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FUSION SEQUENCE

<400>  18
gtggacccgt gcttcagagc caactgcgag taccagtgcc agcccctgaa ccaaactagc       60

tacctctgcg tctgcgccga gggcttcgcg cccattcccc acgagccgca caggtgccag      120

atgttttgca accagactgc ctgtccagcc gactgcgacc ccaacaccca ggctagctgt      180

gagtgccctg aaggctacat cctggacgac ggtttcatct gcacggacat cgacgagtgc      240

gaaaacggcg gcttctgctc cggggtgtgc cacaacctcc ccggtacctt cgagtgcatc      300

tgcgggcccg actcggccct tgcccgccac attggcaccg actgtgactc cggctcaagt      360

tcattcgaca aaggaaaata taaaaaaggc gatgacgcga gttattttga accaacaggc      420

ccgtatttga tggtaaatgt gactggagtt gatagtaaag gaaatgaatt gctatcccct      480

cattatgtcg agtttcctat taaacctggg actacactta caaaagaaaa aattgaatac      540

tatgtcgaat gggcattaga tgcgacagca tataaagagt ttagagtagt tgaattagat      600

ccaagcgcaa agatcgaagt cacttattat gataagaata agaaaaaaga agaaacgaag      660

tctttcccta taacagaaaa aggttttgtt gtcccagatt tatcagagca tattaaaaac      720

cctggattca acttaattac aaaggttgtt atagaaaaga aa                         762


<210>  19
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FUSION SEQUENCE

<400>  19
tcaagttcat tcgacaaagg aaaatataaa aaaggcgatg acgcgagtta ttttgaacca       60

acaggcccgt atttgatggt aaatgtgact ggagttgata gtaaaggaaa tgaattgcta      120

tcccctcatt atgtcgagtt tcctattaaa cctgggacta cacttacaaa agaaaaaatt      180

gaatactatg tcgaatgggc attagatgcg acagcatata aagagtttag agtagttgaa      240

ttagatccaa gcgcaaagat cgaagtcact tattatgata agaataagaa aaaagaagaa      300

acgaagtctt tccctataac agaaaaaggt tttgttgtcc cagatttatc agagcatatt      360

aaaaaccctg gattcaactt aattacaaag gttgttatag aaaagaaaga gcccgtggac      420

ccgtgcttca gagccaactg cgagtaccag tgccagcccc tgaaccaaac tagctacctc      480

tgcgtctgcg ccgagggctt cgcgcccatt ccccacgagc cgcacaggtg ccagatgttt      540

tgcaaccaga ctgcctgtcc agccgactgc gaccccaaca cccaggctag ctgtgagtgc      600

cctgaaggct acatcctgga cgacggtttc atctgcacgg acatcgacga gtgcgaaaac      660

ggcggcttct gctccggggt gtgccacaac ctccccggta ccttcgagtg catctgcggg      720

cccgactcgg cccttgcccg ccacattggc accgactgtg actccggc                   768


<210>  20
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tPA variant

<400>  20
caagagattc atgctagatt cagaagaggt gctagatcct accaggtcat ttgtagagat       60

gaaaagacac aaatgatcta tcaacagcac cagtcatggc ttagacctgt tttgagaagt      120

aacagagtcg agtactgttg gtgcaattct ggtagagccc aatgtcatag tgttccagtc      180

aaatcatgta gtgaacctag atgctttaac ggtggaactt gtcaacaggc tttgtacttc      240

tctgatttcg tttgtcaatg cccagaggga ttcgctggta aatgttgcga aattgacacc      300

agagctactt gttacgaaga tcagggaatc tcatatagag gtaattggtc tacagctgag      360

tccggagccg aatgtactca atggaattct tccgctttgg cccaaaaacc atactctggt      420

agaagacctg atgctattag acttggtttg ggaaaccaca attattgcag aaatccagac      480

agagattcta agccttggtg ttacgttttt aaggccggaa aatattcaag tgaattctgt      540

tccacccctg catgctcaga gggtaacagt gattgttact ttggtaatgg atctgcttat      600

agaggaaccc attccttgac tgagtcaggt gccagttgtc ttccatggaa ctcaatgatt      660

ttgatcggaa aagtttacac tgcacaaaat cctagtgcac aggctcttgg tttgggaaag      720

cataactact gtagaaatcc agacggagat gccaaacctt ggtgtcacgt tcttaagaac      780

agaagattga catgggaata ctgtgacgtc ccatcttgtt ccacctgcgg tttgagacaa      840

tactcacaac ctcagtttag aattaaaggt ggattgttcg ctgatatcgc ctctcatcca      900

tggcaggctg ccatttttgc tgctgccgct gcttcccctg gagagagatt cctttgtggt      960

ggaattttga tctcttcctg ctggattttg tccgcagctc actgttttca agaaagattc     1020

ccacctcatc accttacagt tatcttggga agaacctaca gagttgtccc aggtgaagag     1080

gaacagaagt ttgaggttga aaaatacatt gtccataagg agttcgatga cgatacttat     1140

gacaatgata tcgcactttt gcaattgaag tctgattcaa gtagatgtgc tcaggaatct     1200

tccgttgtca gaactgtttg tttgccacct gctgaccttc aattgcctga ttggacagag     1260

tgtgaacttt ctggttacgg aaaacacgaa gccttgtctc cattttattc cgagagactt     1320

aaggaagcac atgttagatt gtatccttca agtagatgta catcccaaca ccttttgaac     1380

agaactgtca cagacaatat gttgtgtgct ggagatacca gatcaggtgg accacaagcc     1440

aacttgcatg acgcatgcca gggagatagt ggtggacctc ttgtttgttt gaatgacggt     1500

agaatgactc ttgtcggaat tatctcttgg ggtttgggat gtggtcaaaa agatgttcca     1560

ggtgtctaca ctaaggttac aaactatttg gactggatca gagataacat gagacca        1617


<210>  21
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_SK Fp 1

<400>  21
gaatatctcg agaaaagagt ggacccgtgc ttcagagcca                              40

<210>  22
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_SK Rp 2 

<400>  22
gtctagcagc cactcaggtc cagcaatgcc ggagtcacag tcggtgcc                     48
<212> Type : DNA
<211> Length : 48
      SequenceName : 2
      SequenceDescription : 


<210>  23
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_SK Fp3 

<400>  23 
ggcaccgact gtgactccgg cattgctgga cctgagtggc tgctagac                     48

<210>  24
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_SK Rp 4

<400>  24
cctatacgcg gccgcttatt tgtcgttagg gttatcaggt at                           42

<210>  25
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SK_EGF Fp 1 

<400>  25
gcatatctcg agaaaagaat tgctggacct gagtggctgc ta                           42

<210>  26
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SK_EGF Rp 2

<400>  26
gaagcacggg tccaccacaa tttgttgagc ttgtccgcca ccggctaaat gatagctagc        60

<210>  27
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SK_EGF Fp 3  

<400>  27
gctagctatc atttagccgg tggcggacaa gctcaacaaa ttgtggtgga cccgtgcttc        60

<210>  28
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SK_EGF Rp 4

<400>  28
ccatatcgcg gccgcgccgg agtcacagtc ggtgccaat                               39


<210>  29
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID a Fp 1

<400>  29
ggatatctcg agaaaagaat tgctggacct gagtggctgc ta                           42

<210>  30
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID a Rp 2

<400>  30
aagcacgggt ccacgggctc agatttcgct tggttttgta tt                           42

<210>  31
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID EGF Fp 3

<400>  31
aatacaaaac caagcgaaat ctgagcccgt ggacccgtgc tt                           42

<210>  32
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID EGF Rp 4

<400>  32 
tacagtatat tccacatcaa cgccggagtc acagtcagtg ccaa                         44


<210>  33
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID  Fp 5

<400>  33
attggcactg actgtgactc cggcgttgat gtggaatata ctgt                         44

<210>  34
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID ? Rp 6 

<400>  34
aaatatcgcg gccgctttgt cgttagggtt atcaggtata                              40

<210>  35
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind M repV Fp

<400>  35 
cacaggtgtc aggtgttttg caatcagact g                                       31

<210>  36
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind M rep V Rp

<400>  36

cagtctgatt gcaaaacacc tgacacctgt g                                       31

<210>  37
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind M rep A Fp

<400>  37
ccgcacaggt gccaggcttt ttgcaaccag actgcttgtc ca                           42

<210>  38
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind M rep A Rp

<400>  38
tggacaagca gtctggttgc aaaaagcctg gcacctgtgc gg                           42


<210>  39
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind M rep Q Fp

<400>  39
 
cacaggtgtc agcaattttg caaccagaca gcctgt                                  36


<210>  40
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind M rep Q Rp

<400>  40
acaggctgtc tggttgcaaa attgctgaca cctgtg                                  36



<210>  41
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ?SK_EGF Fp 1
gcataactcg agaaaagaga ggcttggctg ctagaccgtc ca                           42


<210>  42
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ?SK_EGF Rp 2

<400>  42
ccatatcgcg gccgcgccgg agtcacagtc ggtgccaat                               39

<210>  43
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_TCS Fp 1

<400>  43
gcctaactcg agaaaagaga gcccgtggac ccgtgcttca ga                           42


<210>  44
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_TCS_Rp2

<400>  44 
gacaattcta ggtttaatgc cagagtcaca gtcggtgcca at                           42


<210>  45
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind TCS_SK Fp 3

<400>  45
ggcattaaac ctagaattgt cggacctgag tggctgctag a                            41


<210>  46
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SK Rp 4

<400>  46 
cctatacgcg gccgcttatt tgtcgttagg gttatcaggt at                           42


<210>  47
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID a Fp1

<400>  47 
ggatatctcg agaaaagaat tgctggacct gagtggctgc ta                           42


<210>  48
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID a Rp2

<400>  48 
ctctgaagca cgggtccacg ggctccaagt gactgcgatc aaa                          43


<210>  49
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind IDE4Fp3

<400>  49 
tttgatcgca gtcacttgga gcccgtggac ccgtgcttca gag                          43


<210>  50
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind IDE6Rp4

<400>  50
aacgtatttg atggtgaaca gtttgccgga gtcacagtcg                              40


<210>  51
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID?Fp5  

<400>  51
cgactgtgac tccggcaaac tgttcaccat caaatacgtt                              40


<210>  52
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind ID ? Rp6

<400>  52
aaatatcgcg gccgctttgt cgttagggtt atcaggtata                              40

<210>  53
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind TG_ N_EGF_ Fp 1  

<400>  53
ggtatcctcg agaaaagagt tcaagcgcaa cagatcgtgg aacccgtgga cccgtgcttc        60
aga                                                                      63


<210>  54
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Afl-II Rp2

<400>  54 
ggttttgatt ttggacttaa gccttgctct gtct                                    34


<210>  55
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_SAK Fp 1

<400>  55
atggatctcg agaaaagagt ggacccgtgc ttcaga                                  36


<210>  56
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_SAK Rp 2

<400>  56
atattttctt tgtcgaatga acttgacatg ccggagtcac agtc                         44
 

<210>  57
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_SAK Fp3

<400>  57
gactgtgact ccggcatgtc aagttcattc gacaaaggaa aatat                        45
 

<210>  58
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EGF_SAK Rp 4

<400>  58
ttatatcgcg gccgcttatt tcttttctat aacaaccttt                              40


<210>  59
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SAK_EGF Fp 1

<400>  59

atccctctcg agaaaagatc aagttcattc gacaaaggaa                              40

 
<210>  60
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SAK_EGF Rp 2

<400>  60

agttggctct gaagcacggg tccacgggct ctttcttttc tataacaacc tt                52


<210>  61
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SAK_EGF Fp 3

<400>  61

aaggttgtta tagaaaagaa agagcccgtg gacccgtgct tcagagccaa ct                52


<210>  62
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SAK_EGF Rp 4

<400>  62
ttttacgcgg ccgctcctga gtcacagtct gtgccaatgt                              40
 

<210>  63
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind BacFp 1

<400>  63
atataggcca tgggtggacc cgtgcttcag agccaact                                38


<210>  64
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind BacRp 2

<400>  64 
cctatatctc gagtttcttt tctataacaa ccttt                                   35
 

<210>  65
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SAK_bac Fp1

<400>  65
atggatccat ggtcaagttc attcgacaaa ggaaaatata                              40



<210>  66
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind SAK_bac Rp2

<400>  66
tatattctcg agtcctgagt cacagtctgt gccaatgt                                38
 

<210>  67
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind E 4 Fp 1

<400>  67
atggatctcg agaaaagagt ggacccgtgc ttcaga                                  36


<210>  68
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind E6 Rp 2

<400>  68
ccgacaattc taggtttaat gccggagtca cagtcagtgc caa                          43



<210>  69
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind TCS SAK Fp 3

<400>  69 
ggcattaaac ctagaattgt cggatcaagt tcattcgata aaggaaaat                    49



<210>  70
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind TCS SAK Rp4

<400>  70
ttatatcgcg gccgcttatt tcttttctat aacaaccttt                              40



<210>  71
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind tPA_Fp 1

<400>  71 
ggataactcg agaaaagaga ggctcaagag attcatgcta gattcaga                     48
 


<210>  72
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind tPA Rp 2

<400>  72
tcatatcgcg gccgctggtc tcatgttatc tctgatccag tcca                         44



<210>  73
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Fin Fp 1

<400>  73
ggataactcg agaaaagaga ggctcaagag attcatgcta gattcaga                     48




<210>  74
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Fin Rp2

<400>  74
ggctctaaag caagggtcaa ctgatttaac tggaacacta tg                           42
 


<210>  75
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind EGF Fp3

<400>  75
catagtgttc cagttaaatc agttgaccct tgctttagag cc                           42



<210>  76
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind EGF RP 4

<400>  76 
agctctggtt ccggaatcac agtcagtacc tatatgtctt gccaa                        45



<210>  77
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind K1 Fp 5

<400>  77
ttggcaagac atataggtac tgactgtgat tccggaacca gagct                        45




<210>  78
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind CD Rp 2

<400>  78 
tcatatcgcg gccgctggtc tcatgttatc tctgatccag tcca                         44
 

<210>  79
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Fg Fp 1

<400>  79
ggataactcg agaaaagaga ggctcaagag attcatgcta gattcaga                     48


<210>  80
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Fg Rp2

<400>  80
tctaaagcaa gggtcaactg atttaactgg aacactatga ca                           42


<210>  81
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind EFI Fp3

<400>  81
tgtcatagtg ttccagttaa atcagttgac ccttgcttta ga                           42


<210>  82
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind EFI RP 4

<400>  82 
atcactgttt ccggaatcac aatcagtacc aatatgtctt gccaa                        45
 

<210>  83
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind K2 Fp 5

<400>  83
ttggcaagac atattggtac tgattgtgat tccggaaaca gtgat                        45


<210>  84
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind K2CD Rp 6

<400>  84
tcatatcgcg gccgctggtc tcatgttatc tctgatccag tcca                         44
 

<210>  85
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EtPA Fp1

<400>  85
ggatatctcg agaaaagagt tgacccttgc ttcagagcca ac                           42
 

<210>  86
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N_EtPA Rp 2

<400>  86
aaagtaacaa tcactatttg acttgactgg aacactatga ca                           42


<210>  87
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind EK2 CD Fp 3

<400>  87
tgtcatagtg ttccagtcaa gtcaaatagt gattgttact tt                           42
 

<210>  88
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind K2 CD Rp 4

<400>  88
tcatatcgcg gccgctggtc tcatgttatc tctgatccag tcca                         44



<210>  89
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Finger  Fp1

<400>  89
ggataactcg agaaaagaga ggctcaagag attcatgcta gattcaga                     48
 

<210>  90
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Finger Rp 2

<400>  90
aaagtaacaa tcactatttg acttgactgg aacactatga ca                           42


<210>  91
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind K2 CD Fp 3

<400>  91 
tgtcatagtg ttccagtcaa gtcaaatagt gattgttact tt                           42


<210>  92
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind EGF Rp 4

<400>  92
ccatatcgcg gccgcttaac ctgagtcaca atctgttcca ata                          43


<210>  93
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind EGF CD Fp1

<400>  93
gttgaccctt gctttagagc caactgtgaa taccaatgcc ag                           42


<210>  94
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind EF CD Rp 2

<400>  94
ctggcattgg tattcacagt tggctctaaa gcaagggtca ac                           42


<210>  95
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind K2 CD Fp 3

<400>  95
gttgaccctt gctttagagc caactgtgaa taccaatgcc ag                           42
 

<210>  96
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind K2 CD Rp 4

<400>  96 
tttatacgcg gccgctggtc tcatgttatc tctgatccag t                            41


<210>  97
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Met rep Val Fp

<400>  97 
catgaaccac atagatgtca agtattctgc aaccagactg                              40


<210>  98
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Met rep Val Rp

<400>  98 
cagtctggtt gcagaatact tgacatctat gtggttcatg                              40


<210>  99
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Met rep Ala Fp

<400>  99
catgaaccac atagatgtca agcattctgc aaccagactg                              40


<210>  100
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Met rep Ala Rp

<400>  100 
cagtctggtt gcagaatgct tgacatctat gtggttcatg                              40


<210>  101
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Met rep Glu Fp

<400>  101
catgaaccac atagatgtca acaattctgc aaccagactg                              40
 

<210>  102
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind Met rep Glu Rp

<400>  102
cagtctggtt gcagaattgt tgacatctat gtggttcatg                              40


<210>  103
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind T 115 N Fp

<400>  103
cagggaatct catatagagg taattggtct acagctgagt                              40


<210>  104
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind T 115 N Rp

<400>  104
actcagctgt agaccaatta cctctatatg agattccctg                              40
 

<210>  105
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N129 Q Fp

<400>  105 
aatgtactaa ctggcaatct tccgctttgg c                                       31


<210>  106
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind N129 Q Rp

<400>  106 
gccaaagcgg aagattgcca gttagtacat t                                       31


<210>  107
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind KH Fp 1

<400>  107
ggataactcg agaaaagaga ggctcaagag attcatgcta gattcaga                     48


<210>  108
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind KH Rp 2

<400>  108 
agcagcggca gcagcaaaaa tggcagcctg cca                                     33


<210>  109
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind KH Fp 3

<400>  109
gctgctgccg ctgcttcccc tggagagaga ttccttt                                 37
 

<210>  110
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer_bind KH Rp4

<400>  110 
tcatatcgcg gccgctggtc tcatgttatc tctgatccag tcca                         44

                        
<210>  111
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  111

Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu 
1               5                   10                  15      


Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile 
            20                  25                  30          


Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys 
        35                  40                  45              


Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu 
    50                  55                  60                  


Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys 
65                  70                  75                  80  


Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr 
                85                  90                  95      


Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly 
            100                 105                 110         


Thr Asp Cys Asp Ser Gly 
        115             


<210>  112
<211>  414
<212>  PRT
<213>  Streptococcus equisimilis

<400>  112

Ile Ala Gly Pro Glu Trp Leu Leu Asp Arg Pro Ser Val Asn Asn Ser 
1               5                   10                  15      


Gln Leu Val Val Ser Val Ala Gly Thr Val Glu Gly Thr Asn Gln Asp 
            20                  25                  30          


Ile Ser Leu Lys Phe Phe Glu Ile Asp Leu Thr Ser Arg Pro Ala His 
        35                  40                  45              


Gly Gly Lys Thr Glu Gln Gly Leu Ser Pro Lys Ser Lys Pro Phe Ala 
    50                  55                  60                  


Thr Asp Ser Gly Ala Met Ser His Lys Leu Glu Lys Ala Asp Leu Leu 
65                  70                  75                  80  


Lys Ala Ile Gln Glu Gln Leu Ile Ala Asn Val His Ser Asn Asp Asp 
                85                  90                  95      


Tyr Phe Glu Val Ile Asp Phe Ala Ser Asp Ala Thr Ile Thr Asp Arg 
            100                 105                 110         


Asn Gly Lys Val Tyr Phe Ala Asp Lys Asp Gly Ser Val Thr Leu Pro 
        115                 120                 125             


Thr Gln Pro Val Gln Glu Phe Leu Leu Ser Gly His Val Arg Val Arg 
    130                 135                 140                 


Pro Tyr Lys Glu Lys Pro Ile Gln Asn Gln Ala Lys Ser Val Asp Val 
145                 150                 155                 160 


Glu Tyr Thr Val Gln Phe Thr Pro Leu Asn Pro Asp Asp Asp Phe Arg 
                165                 170                 175     


Pro Gly Leu Lys Asp Thr Lys Leu Leu Lys Thr Leu Ala Ile Gly Asp 
            180                 185                 190         


Thr Ile Thr Ser Gln Glu Leu Leu Ala Gln Ala Gln Ser Ile Leu Asn 
        195                 200                 205             


Lys Asn His Pro Gly Tyr Thr Ile Tyr Glu Arg Asp Ser Ser Ile Val 
    210                 215                 220                 


Thr His Asp Asn Asp Ile Phe Arg Thr Ile Leu Pro Met Asp Gln Glu 
225                 230                 235                 240 


Phe Thr Tyr Arg Val Lys Asn Arg Glu Gln Ala Tyr Arg Ile Asn Lys 
                245                 250                 255     


Lys Ser Gly Leu Asn Glu Glu Ile Asn Asn Thr Asp Leu Ile Ser Glu 
            260                 265                 270         


Lys Tyr Tyr Val Leu Lys Lys Gly Glu Lys Pro Tyr Asp Pro Phe Asp 
        275                 280                 285             


Arg Ser His Leu Lys Leu Phe Thr Ile Lys Tyr Val Asp Val Asp Thr 
    290                 295                 300                 


Asn Glu Leu Leu Lys Ser Glu Gln Leu Leu Thr Ala Ser Glu Arg Asn 
305                 310                 315                 320 


Leu Asp Phe Arg Asp Leu Tyr Asp Pro Arg Asp Lys Ala Lys Leu Leu 
                325                 330                 335     


Tyr Asn Asn Leu Asp Ala Phe Gly Ile Met Asp Tyr Thr Leu Thr Gly 
            340                 345                 350         


Lys Val Glu Asp Asn His Asp Asp Thr Asn Arg Ile Ile Thr Val Tyr 
        355                 360                 365             


Met Gly Lys Arg Pro Glu Gly Glu Asn Ala Ser Tyr His Leu Ala Tyr 
    370                 375                 380                 


Asp Lys Asp Arg Tyr Thr Glu Glu Glu Arg Glu Val Tyr Ser Tyr Leu 
385                 390                 395                 400 


Arg Tyr Thr Gly Thr Pro Ile Pro Asp Asn Pro Asn Asp Lys 
                405                 410                 


<210>  113
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTIEN

<400>  113

Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu 
1               5                   10                  15      


Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile 
            20                  25                  30          


Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys 
        35                  40                  45              


Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu 
    50                  55                  60                  


Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys 
65                  70                  75                  80  


Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr 
                85                  90                  95      


Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly 
            100                 105                 110         


Thr Asp Cys Asp Ser Gly Ile Ala Gly Pro Glu Trp Leu Leu Asp Arg 
        115                 120                 125             


Pro Ser Val Asn Asn Ser Gln Leu Val Val Ser Val Ala Gly Thr Val 
    130                 135                 140                 


Glu Gly Thr Asn Gln Asp Ile Ser Leu Lys Phe Phe Glu Ile Asp Leu 
145                 150                 155                 160 


Thr Ser Arg Pro Ala His Gly Gly Lys Thr Glu Gln Gly Leu Ser Pro 
                165                 170                 175     


Lys Ser Lys Pro Phe Ala Thr Asp Ser Gly Ala Met Ser His Lys Leu 
            180                 185                 190         


Glu Lys Ala Asp Leu Leu Lys Ala Ile Gln Glu Gln Leu Ile Ala Asn 
        195                 200                 205             


Val His Ser Asn Asp Asp Tyr Phe Glu Val Ile Asp Phe Ala Ser Asp 
    210                 215                 220                 


Ala Thr Ile Thr Asp Arg Asn Gly Lys Val Tyr Phe Ala Asp Lys Asp 
225                 230                 235                 240 


Gly Ser Val Thr Leu Pro Thr Gln Pro Val Gln Glu Phe Leu Leu Ser 
                245                 250                 255     


Gly His Val Arg Val Arg Pro Tyr Lys Glu Lys Pro Ile Gln Asn Gln 
            260                 265                 270         


Ala Lys Ser Val Asp Val Glu Tyr Thr Val Gln Phe Thr Pro Leu Asn 
        275                 280                 285             


Pro Asp Asp Asp Phe Arg Pro Gly Leu Lys Asp Thr Lys Leu Leu Lys 
    290                 295                 300                 


Thr Leu Ala Ile Gly Asp Thr Ile Thr Ser Gln Glu Leu Leu Ala Gln 
305                 310                 315                 320 


Ala Gln Ser Ile Leu Asn Lys Asn His Pro Gly Tyr Thr Ile Tyr Glu 
                325                 330                 335     


Arg Asp Ser Ser Ile Val Thr His Asp Asn Asp Ile Phe Arg Thr Ile 
            340                 345                 350         


Leu Pro Met Asp Gln Glu Phe Thr Tyr Arg Val Lys Asn Arg Glu Gln 
        355                 360                 365             


Ala Tyr Arg Ile Asn Lys Lys Ser Gly Leu Asn Glu Glu Ile Asn Asn 
    370                 375                 380                 


Thr Asp Leu Ile Ser Glu Lys Tyr Tyr Val Leu Lys Lys Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Asp Pro Phe Asp Arg Ser His Leu Lys Leu Phe Thr Ile Lys 
                405                 410                 415     


Tyr Val Asp Val Asp Thr Asn Glu Leu Leu Lys Ser Glu Gln Leu Leu 
            420                 425                 430         


Thr Ala Ser Glu Arg Asn Leu Asp Phe Arg Asp Leu Tyr Asp Pro Arg 
        435                 440                 445             


Asp Lys Ala Lys Leu Leu Tyr Asn Asn Leu Asp Ala Phe Gly Ile Met 
    450                 455                 460                 


Asp Tyr Thr Leu Thr Gly Lys Val Glu Asp Asn His Asp Asp Thr Asn 
465                 470                 475                 480 


Arg Ile Ile Thr Val Tyr Met Gly Lys Arg Pro Glu Gly Glu Asn Ala 
                485                 490                 495     


Ser Tyr His Leu Ala Tyr Asp Lys Asp Arg Tyr Thr Glu Glu Glu Arg 
            500                 505                 510         


Glu Val Tyr Ser Tyr Leu Arg Tyr Thr Gly Thr Pro Ile Pro Asp Asn 
        515                 520                 525             


Pro Asn Asp Lys 
    530         


<210>  114
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  114

Ile Ala Gly Pro Glu Trp Leu Leu Asp Arg Pro Ser Val Asn Asn Ser 
1               5                   10                  15      


Gln Leu Val Val Ser Val Ala Gly Thr Val Glu Gly Thr Asn Gln Asp 
            20                  25                  30          


Ile Ser Leu Lys Phe Phe Glu Ile Asp Leu Thr Ser Arg Pro Ala His 
        35                  40                  45              


Gly Gly Lys Thr Glu Gln Gly Leu Ser Pro Lys Ser Lys Pro Phe Ala 
    50                  55                  60                  


Thr Asp Ser Gly Ala Met Ser His Lys Leu Glu Lys Ala Asp Leu Leu 
65                  70                  75                  80  


Lys Ala Ile Gln Glu Gln Leu Ile Ala Asn Val His Ser Asn Asp Asp 
                85                  90                  95      


Tyr Phe Glu Val Ile Asp Phe Ala Ser Asp Ala Thr Ile Thr Asp Arg 
            100                 105                 110         


Asn Gly Lys Val Tyr Phe Ala Asp Lys Asp Gly Ser Val Thr Leu Pro 
        115                 120                 125             


Thr Gln Pro Val Gln Glu Phe Leu Leu Ser Gly His Val Arg Val Arg 
    130                 135                 140                 


Pro Tyr Lys Glu Lys Pro Ile Gln Asn Gln Ala Lys Ser Val Asp Val 
145                 150                 155                 160 


Glu Tyr Thr Val Gln Phe Thr Pro Leu Asn Pro Asp Asp Asp Phe Arg 
                165                 170                 175     


Pro Gly Leu Lys Asp Thr Lys Leu Leu Lys Thr Leu Ala Ile Gly Asp 
            180                 185                 190         


Thr Ile Thr Ser Gln Glu Leu Leu Ala Gln Ala Gln Ser Ile Leu Asn 
        195                 200                 205             


Lys Asn His Pro Gly Tyr Thr Ile Tyr Glu Arg Asp Ser Ser Ile Val 
    210                 215                 220                 


Thr His Asp Asn Asp Ile Phe Arg Thr Ile Leu Pro Met Asp Gln Glu 
225                 230                 235                 240 


Phe Thr Tyr Arg Val Lys Asn Arg Glu Gln Ala Tyr Arg Ile Asn Lys 
                245                 250                 255     


Lys Ser Gly Leu Asn Glu Glu Ile Asn Asn Thr Asp Leu Ile Ser Glu 
            260                 265                 270         


Lys Tyr Tyr Val Leu Lys Lys Gly Glu Lys Pro Tyr Asp Pro Phe Asp 
        275                 280                 285             


Arg Ser His Leu Lys Leu Phe Thr Ile Lys Tyr Val Asp Val Asp Thr 
    290                 295                 300                 


Asn Glu Leu Leu Lys Ser Glu Gln Leu Leu Thr Ala Ser Glu Arg Asn 
305                 310                 315                 320 


Leu Asp Phe Arg Asp Leu Tyr Asp Pro Arg Asp Lys Ala Lys Leu Leu 
                325                 330                 335     


Tyr Asn Asn Leu Asp Ala Phe Gly Ile Met Asp Tyr Thr Leu Thr Gly 
            340                 345                 350         


Lys Val Glu Asp Asn His Asp Asp Thr Asn Arg Ile Ile Thr Val Tyr 
        355                 360                 365             


Met Gly Lys Arg Pro Glu Gly Glu Asn Ala Ser Tyr His Leu Ala Gly 
    370                 375                 380                 


Gly Gly Val Gln Ala Gln Gln Ile Val Val Asp Pro Cys Phe Arg Ala 
385                 390                 395                 400 


Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu Cys 
                405                 410                 415     


Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His Arg Cys 
            420                 425                 430         


Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro Asn 
        435                 440                 445             


Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp Gly 
    450                 455                 460                 


Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser 
465                 470                 475                 480 


Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly Pro 
                485                 490                 495     


Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser Gly 
            500                 505                 510     


<210>  115
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  115

Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu 
1               5                   10                  15      


Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile 
            20                  25                  30          


Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys 
        35                  40                  45              


Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu 
    50                  55                  60                  


Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys 
65                  70                  75                  80  


Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr 
                85                  90                  95      


Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly 
            100                 105                 110         


Thr Asp Cys Asp Ser Gly Ile Ala Gly Pro Glu Trp Leu Leu Asp Arg 
        115                 120                 125             


Pro Ser Val Asn Asn Ser Gln Leu Val Val Ser Val Ala Gly Thr Val 
    130                 135                 140                 


Glu Gly Thr Asn Gln Asp Ile Ser Leu Lys Phe Phe Glu Ile Asp Leu 
145                 150                 155                 160 


Thr Ser Arg Pro Ala His Gly Gly Lys Thr Glu Gln Gly Leu Ser Pro 
                165                 170                 175     


Lys Ser Lys Pro Phe Ala Thr Asp Ser Gly Ala Met Ser His Lys Leu 
            180                 185                 190         


Glu Lys Ala Asp Leu Leu Lys Ala Ile Gln Glu Gln Leu Ile Ala Asn 
        195                 200                 205             


Val His Ser Asn Asp Asp Tyr Phe Glu Val Ile Asp Phe Ala Ser Asp 
    210                 215                 220                 


Ala Thr Ile Thr Asp Arg Asn Gly Lys Val Tyr Phe Ala Asp Lys Asp 
225                 230                 235                 240 


Gly Ser Val Thr Leu Pro Thr Gln Pro Val Gln Glu Phe Leu Leu Ser 
                245                 250                 255     


Gly His Val Arg Val Arg Pro Tyr Lys Glu Lys Pro Ile Gln Asn Gln 
            260                 265                 270         


Ala Lys Ser Val Asp Val Glu Tyr Thr Val Gln Phe Thr Pro Leu Asn 
        275                 280                 285             


Pro Asp Asp Asp Phe Arg Pro Gly Leu Lys Asp Thr Lys Leu Leu Lys 
    290                 295                 300                 


Thr Leu Ala Ile Gly Asp Thr Ile Thr Ser Gln Glu Leu Leu Ala Gln 
305                 310                 315                 320 


Ala Gln Ser Ile Leu Asn Lys Asn His Pro Gly Tyr Thr Ile Tyr Glu 
                325                 330                 335     


Arg Asp Ser Ser Ile Val Thr His Asp Asn Asp Ile Phe Arg Thr Ile 
            340                 345                 350         


Leu Pro Met Asp Gln Glu Phe Thr Tyr Arg Val Lys Asn Arg Glu Gln 
        355                 360                 365             


Ala Tyr Arg Ile Asn Lys Lys Ser Gly Leu Asn Glu Glu Ile Asn Asn 
    370                 375                 380                 


Thr Asp Leu Ile Ser Glu Lys Tyr Tyr Val Leu Lys Lys Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Asp Pro Phe Asp Arg Ser His Leu Lys Leu Phe Thr Ile Lys 
                405                 410                 415     


Tyr Val Asp Val Asp Thr Asn Glu Leu Leu Lys Ser Glu Gln Leu Leu 
            420                 425                 430         


Thr Ala Ser Glu Arg Asn Leu Asp Phe Arg Asp Leu Tyr Asp Pro Arg 
        435                 440                 445             


Asp Lys Ala Lys Leu Leu Tyr Asn Asn Leu Asp Ala Phe Gly Ile Met 
    450                 455                 460                 


Asp Tyr Thr Leu Thr Gly Lys Val Glu Asp Asn His Asp Asp Thr Asn 
465                 470                 475                 480 


Arg Ile Ile Thr Val Tyr Met Gly Lys Arg Pro Glu Gly Glu Asn Ala 
                485                 490                 495     


Ser Tyr His Leu Ala Gly Gly Gly Val Gln Ala Gln Gln Ile Val Val 
            500                 505                 510         


Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn 
        515                 520                 525             


Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro 
    530                 535                 540                 


His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro 
545                 550                 555                 560 


Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly 
                565                 570                 575     


Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu 
            580                 585                 590         


Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe 
        595                 600                 605             


Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr 
    610                 615                 620                 


Asp Cys Asp Ser Gly 
625                 


<210>  116
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  116

Ile Ala Gly Pro Glu Trp Leu Leu Asp Arg Pro Ser Val Asn Asn Ser 
1               5                   10                  15      


Gln Leu Val Val Ser Val Ala Gly Thr Val Glu Gly Thr Asn Gln Asp 
            20                  25                  30          


Ile Ser Leu Lys Phe Phe Glu Ile Asp Leu Thr Ser Arg Pro Ala His 
        35                  40                  45              


Gly Gly Lys Thr Glu Gln Gly Leu Ser Pro Lys Ser Lys Pro Phe Ala 
    50                  55                  60                  


Thr Asp Ser Gly Ala Met Ser His Lys Leu Glu Lys Ala Asp Leu Leu 
65                  70                  75                  80  


Lys Ala Ile Gln Glu Gln Leu Ile Ala Asn Val His Ser Asn Asp Asp 
                85                  90                  95      


Tyr Phe Glu Val Ile Asp Phe Ala Ser Asp Ala Thr Ile Thr Asp Arg 
            100                 105                 110         


Asn Gly Lys Val Tyr Phe Ala Asp Lys Asp Gly Ser Val Thr Leu Pro 
        115                 120                 125             


Thr Gln Pro Val Gln Glu Phe Leu Leu Ser Gly His Val Arg Val Arg 
    130                 135                 140                 


Pro Tyr Lys Glu Lys Pro Ile Gln Asn Gln Ala Lys Ser Glu Pro Val 
145                 150                 155                 160 


Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn 
                165                 170                 175     


Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro 
            180                 185                 190         


His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro 
        195                 200                 205             


Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly 
    210                 215                 220                 


Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu 
225                 230                 235                 240 


Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe 
                245                 250                 255     


Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr 
            260                 265                 270         


Asp Cys Asp Ser Gly Val Asp Val Glu Tyr Thr Val Gln Phe Thr Pro 
        275                 280                 285             


Leu Asn Pro Asp Asp Asp Phe Arg Pro Gly Leu Lys Asp Thr Lys Leu 
    290                 295                 300                 


Leu Lys Thr Leu Ala Ile Gly Asp Thr Ile Thr Ser Gln Glu Leu Leu 
305                 310                 315                 320 


Ala Gln Ala Gln Ser Ile Leu Asn Lys Asn His Pro Gly Tyr Thr Ile 
                325                 330                 335     


Tyr Glu Arg Asp Ser Ser Ile Val Thr His Asp Asn Asp Ile Phe Arg 
            340                 345                 350         


Thr Ile Leu Pro Met Asp Gln Glu Phe Thr Tyr Arg Val Lys Asn Arg 
        355                 360                 365             


Glu Gln Ala Tyr Arg Ile Asn Lys Lys Ser Gly Leu Asn Glu Glu Ile 
    370                 375                 380                 


Asn Asn Thr Asp Leu Ile Ser Glu Lys Tyr Tyr Val Leu Lys Lys Gly 
385                 390                 395                 400 


Glu Lys Pro Tyr Asp Pro Phe Asp Arg Ser His Leu Lys Leu Phe Thr 
                405                 410                 415     


Ile Lys Tyr Val Asp Val Asp Thr Asn Glu Leu Leu Lys Ser Glu Gln 
            420                 425                 430         


Leu Leu Thr Ala Ser Glu Arg Asn Leu Asp Phe Arg Asp Leu Tyr Asp 
        435                 440                 445             


Pro Arg Asp Lys Ala Lys Leu Leu Tyr Asn Asn Leu Asp Ala Phe Gly 
    450                 455                 460                 


Ile Met Asp Tyr Thr Leu Thr Gly Lys Val Glu Asp Asn His Asp Asp 
465                 470                 475                 480 


Thr Asn Arg Ile Ile Thr Val Tyr Met Gly Lys Arg Pro Glu Gly Glu 
                485                 490                 495     


Asn Ala Ser Tyr His Leu Ala Tyr Asp Lys Asp Arg Tyr Thr Glu Glu 
            500                 505                 510         


Glu Arg Glu Val Tyr Ser Tyr Leu Arg Tyr Thr Gly Thr Pro Ile Pro 
        515                 520                 525             


Asp Asn Pro Asn Asp Lys 
    530                 


<210>  117
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  117

Val Gln Ala Gln Gln Ile Val Val Asp Pro Cys Phe Arg Ala Asn Cys 
1               5                   10                  15      


Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys 
            20                  25                  30          


Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His Arg Cys Gln Val 
        35                  40                  45              


Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln 
    50                  55                  60                  


Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile 
65                  70                  75                  80  


Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser Gly Val 
                85                  90                  95      


Cys His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser 
            100                 105                 110         


Ala Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser Gly Ile Lys Pro 
        115                 120                 125             


Arg Ile Val Gly Ile Ala Gly Pro Glu Trp Leu Leu Asp Arg Pro Ser 
    130                 135                 140                 


Val Asn Asn Ser Gln Leu Val Val Ser Val Ala Gly Thr Val Glu Gly 
145                 150                 155                 160 


Thr Asn Gln Asp Ile Ser Leu Lys Phe Phe Glu Ile Asp Leu Thr Ser 
                165                 170                 175     


Arg Pro Ala His Gly Gly Lys Thr Glu Gln Gly Leu Ser Pro Lys Ser 
            180                 185                 190         


Lys Pro Phe Ala Thr Asp Ser Gly Ala Met Ser His Lys Leu Glu Lys 
        195                 200                 205             


Ala Asp Leu Leu Lys Ala Ile Gln Glu Gln Leu Ile Ala Asn Val His 
    210                 215                 220                 


Ser Asn Asp Asp Tyr Phe Glu Val Ile Asp Phe Ala Ser Asp Ala Thr 
225                 230                 235                 240 


Ile Thr Asp Arg Asn Gly Lys Val Tyr Phe Ala Asp Lys Asp Gly Ser 
                245                 250                 255     


Val Thr Leu Pro Thr Gln Pro Val Gln Glu Phe Leu Leu Ser Gly His 
            260                 265                 270         


Val Arg Val Arg Pro Tyr Lys Glu Lys Pro Ile Gln Asn Gln Ala Lys 
        275                 280                 285             


Ser Val Asp Val Glu Tyr Thr Val Gln Phe Thr Pro Leu Asn Pro Asp 
    290                 295                 300                 


Asp Asp Phe Arg Pro Gly Leu Lys Asp Thr Lys Leu Leu Lys Thr Leu 
305                 310                 315                 320 


Ala Ile Gly Asp Thr Ile Thr Ser Gln Glu Leu Leu Ala Gln Ala Gln 
                325                 330                 335     


Ser Ile Leu Asn Lys Asn His Pro Gly Tyr Thr Ile Tyr Glu Arg Asp 
            340                 345                 350         


Ser Ser Ile Val Thr His Asp Asn Asp Ile Phe Arg Thr Ile Leu Pro 
        355                 360                 365             


Met Asp Gln Glu Phe Thr Tyr Arg Val Lys Asn Arg Glu Gln Ala Tyr 
    370                 375                 380                 


Arg Ile Asn Lys Lys Ser Gly Leu Asn Glu Glu Ile Asn Asn Thr Asp 
385                 390                 395                 400 


Leu Ile Ser Glu Lys Tyr Tyr Val Leu Lys Lys Gly Glu Lys Pro Tyr 
                405                 410                 415     


Asp Pro Phe Asp Arg Ser His Leu Lys Leu Phe Thr Ile Lys Tyr Val 
            420                 425                 430         


Asp Val Asp Thr Asn Glu Leu Leu Lys Ser Glu Gln Leu Leu Thr Ala 
        435                 440                 445             


Ser Glu Arg Asn Leu Asp Phe Arg Asp Leu Tyr Asp Pro Arg Asp Lys 
    450                 455                 460                 


Ala Lys Leu Leu Tyr Asn Asn Leu Asp Ala Phe Gly Ile Met Asp Tyr 
465                 470                 475                 480 


Thr Leu Thr Gly Lys Val Glu Asp Asn His Asp Asp Thr Asn Arg Ile 
                485                 490                 495     


Ile Thr Val Tyr Met Gly Lys Arg Pro Glu Gly Glu Asn Ala Ser Tyr 
            500                 505                 510         


His Leu Ala Gly Gly Gly Val Gln Ala Gln Gln Ile Val Val Asp Pro 
        515                 520                 525             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    530                 535                 540                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
545                 550                 555                 560 


Pro His Arg Cys Gln Val Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                565                 570                 575     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            580                 585                 590         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        595                 600                 605             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    610                 615                 620                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
625                 630                 635                 640 


Asp Ser Gly 
            


<210>  118
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  118

Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu 
1               5                   10                  15      


Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile 
            20                  25                  30          


Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys 
        35                  40                  45              


Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu 
    50                  55                  60                  


Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys 
65                  70                  75                  80  


Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr 
                85                  90                  95      


Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly 
            100                 105                 110         


Thr Asp Cys Asp Ser Gly Gly Gly Pro Gln Val Lys 
        115                 120                 


<210>  119
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  119

Ser Ser Ser Phe Asp Lys Gly Lys Tyr Lys Lys Gly Asp Asp Ala Ser 
1               5                   10                  15      


Tyr Phe Glu Pro Thr Gly Pro Tyr Leu Met Val Asn Val Thr Gly Val 
            20                  25                  30          


Asp Ser Lys Gly Asn Glu Leu Leu Ser Pro His Tyr Val Glu Phe Pro 
        35                  40                  45              


Ile Lys Pro Gly Thr Thr Leu Thr Lys Glu Lys Ile Glu Tyr Tyr Val 
    50                  55                  60                  


Glu Trp Ala Leu Asp Ala Thr Ala Tyr Lys Glu Phe Arg Val Val Glu 
65                  70                  75                  80  


Leu Asp Pro Ser Ala Lys Ile Glu Val Thr Tyr Tyr Asp Lys Asn Lys 
                85                  90                  95      


Lys Lys Glu Glu Thr Lys Ser Phe Pro Ile Thr Glu Lys Gly Phe Val 
            100                 105                 110         


Val Pro Asp Leu Ser Glu His Ile Lys Asn Pro Gly Phe Asn Leu Ile 
        115                 120                 125             


Thr Lys Val Val Ile Glu Lys Lys Glu Pro Val Asp Pro Cys Phe Arg 
    130                 135                 140                 


Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu 
145                 150                 155                 160 


Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His Arg 
                165                 170                 175     


Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro 
            180                 185                 190         


Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp 
        195                 200                 205             


Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys 
    210                 215                 220                 


Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly 
225                 230                 235                 240 


Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser Gly 
                245                 250                 255     


<210>  120
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FROM CUSTOME SYNTHESIZED DNA

<400>  120

Gln Glu Ile His Ala Arg Phe Arg Arg Gly Ala Arg Ser Tyr Gln Val 
1               5                   10                  15      


Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser 
            20                  25                  30          


Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys 
        35                  40                  45              


Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val Lys Ser Cys Ser 
    50                  55                  60                  


Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu Tyr Phe 
65                  70                  75                  80  


Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys Cys Cys 
                85                  90                  95      


Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser Tyr 
            100                 105                 110         


Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp 
        115                 120                 125             


Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg Pro Asp 
    130                 135                 140                 


Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp 
145                 150                 155                 160 


Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser 
                165                 170                 175     


Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp Cys 
            180                 185                 190         


Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr Glu 
        195                 200                 205             


Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly Lys 
    210                 215                 220                 


Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly Lys 
225                 230                 235                 240 


His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His 
                245                 250                 255     


Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys Asp Val Pro Ser 
            260                 265                 270         


Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Arg Ile 
        275                 280                 285             


Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala 
    290                 295                 300                 


Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly 
305                 310                 315                 320 


Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe 
                325                 330                 335     


Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr 
            340                 345                 350         


Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys 
        355                 360                 365             


Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile 
    370                 375                 380                 


Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser 
385                 390                 395                 400 


Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro 
                405                 410                 415     


Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu 
            420                 425                 430         


Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr 
        435                 440                 445             


Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr 
    450                 455                 460                 


Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala 
465                 470                 475                 480 


Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
                485                 490                 495     


Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu 
            500                 505                 510         


Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn 
        515                 520                 525             


Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
    530                 535                 


<210>  121
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  121

Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu 
1               5                   10                  15      


Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile 
            20                  25                  30          


Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys 
        35                  40                  45              


Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu 
    50                  55                  60                  


Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys 
65                  70                  75                  80  


Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr 
                85                  90                  95      


Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly 
            100                 105                 110         


Thr Asp Cys Asp Ser Gly Gln Glu Ile His Ala Arg Phe Arg Arg Gly 
        115                 120                 125             


Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile 
    130                 135                 140                 


Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg 
145                 150                 155                 160 


Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val 
                165                 170                 175     


Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys 
            180                 185                 190         


Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly 
        195                 200                 205             


Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu 
    210                 215                 220                 


Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly 
225                 230                 235                 240 


Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr 
                245                 250                 255     


Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn 
            260                 265                 270         


Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe 
        275                 280                 285             


Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser 
    290                 295                 300                 


Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly 
305                 310                 315                 320 


Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser 
                325                 330                 335     


Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln 
            340                 345                 350         


Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp 
        355                 360                 365             


Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu 
    370                 375                 380                 


Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser 
385                 390                 395                 400 


Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser 
                405                 410                 415     


His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly 
            420                 425                 430         


Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu 
        435                 440                 445             


Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr 
    450                 455                 460                 


Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln 
465                 470                 475                 480 


Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp 
                485                 490                 495     


Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser 
            500                 505                 510         


Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro 
        515                 520                 525             


Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr 
    530                 535                 540                 


Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu 
545                 550                 555                 560 


Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu 
                565                 570                 575     


Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg 
            580                 585                 590         


Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser 
        595                 600                 605             


Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly 
    610                 615                 620                 


Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val 
625                 630                 635                 640 


Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg 
                645                 650                 655     


Pro Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro 
            660                 665                 670         


Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro 
        675                 680                 685             


Ile Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala 
    690                 695                 700                 


Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro 
705                 710                 715                 720 


Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu 
                725                 730                 735     


Cys Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly 
            740                 745                 750         


Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile 
        755                 760                 765             


Gly Thr Asp Cys Asp Ser Gly 
    770                 775 


<210>  122
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  122

Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu 
1               5                   10                  15      


Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile 
            20                  25                  30          


Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys 
        35                  40                  45              


Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu 
    50                  55                  60                  


Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys 
65                  70                  75                  80  


Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr 
                85                  90                  95      


Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly 
            100                 105                 110         


Thr Asp Cys Asp Ser Gly Gln Glu Ile His Ala Arg Phe Arg Arg Gly 
        115                 120                 125             


Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile 
    130                 135                 140                 


Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg 
145                 150                 155                 160 


Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val 
                165                 170                 175     


Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys 
            180                 185                 190         


Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly 
        195                 200                 205             


Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu 
    210                 215                 220                 


Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly 
225                 230                 235                 240 


Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr 
                245                 250                 255     


Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn 
            260                 265                 270         


Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe 
        275                 280                 285             


Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser 
    290                 295                 300                 


Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly 
305                 310                 315                 320 


Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser 
                325                 330                 335     


Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln 
            340                 345                 350         


Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp 
        355                 360                 365             


Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu 
    370                 375                 380                 


Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser 
385                 390                 395                 400 


Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser 
                405                 410                 415     


His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly 
            420                 425                 430         


Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu 
        435                 440                 445             


Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr 
    450                 455                 460                 


Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln 
465                 470                 475                 480 


Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp 
                485                 490                 495     


Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser 
            500                 505                 510         


Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro 
        515                 520                 525             


Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr 
    530                 535                 540                 


Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu 
545                 550                 555                 560 


Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu 
                565                 570                 575     


Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg 
            580                 585                 590         


Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser 
        595                 600                 605             


Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly 
    610                 615                 620                 


Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val 
625                 630                 635                 640 


Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg 
                645                 650                 655     


Pro 
    


<210>  123
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  123

Gln Glu Ile His Ala Arg Phe Arg Arg Gly Ala Arg Ser Tyr Gln Val 
1               5                   10                  15      


Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser 
            20                  25                  30          


Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys 
        35                  40                  45              


Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val Lys Ser Cys Ser 
    50                  55                  60                  


Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu Tyr Phe 
65                  70                  75                  80  


Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys Cys Cys 
                85                  90                  95      


Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser Tyr 
            100                 105                 110         


Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp 
        115                 120                 125             


Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg Pro Asp 
    130                 135                 140                 


Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp 
145                 150                 155                 160 


Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser 
                165                 170                 175     


Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp Cys 
            180                 185                 190         


Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr Glu 
        195                 200                 205             


Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly Lys 
    210                 215                 220                 


Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly Lys 
225                 230                 235                 240 


His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His 
                245                 250                 255     


Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys Asp Val Pro Ser 
            260                 265                 270         


Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Arg Ile 
        275                 280                 285             


Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala 
    290                 295                 300                 


Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly 
305                 310                 315                 320 


Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe 
                325                 330                 335     


Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr 
            340                 345                 350         


Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys 
        355                 360                 365             


Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile 
    370                 375                 380                 


Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser 
385                 390                 395                 400 


Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro 
                405                 410                 415     


Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu 
            420                 425                 430         


Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr 
        435                 440                 445             


Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr 
    450                 455                 460                 


Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala 
465                 470                 475                 480 


Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
                485                 490                 495     


Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu 
            500                 505                 510         


Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn 
        515                 520                 525             


Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro Val Asp Pro Cys Phe 
    530                 535                 540                 


Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr 
545                 550                 555                 560 


Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His 
                565                 570                 575     


Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp 
            580                 585                 590         


Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp 
        595                 600                 605             


Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe 
    610                 615                 620                 


Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys 
625                 630                 635                 640 


Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser 
                645                 650                 655     


Gly 
    


<210>  124
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  124

Gln Glu Ile His Ala Arg Phe Arg Arg Gly Ala Arg Ser Tyr Gln Val 
1               5                   10                  15      


Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser 
            20                  25                  30          


Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys 
        35                  40                  45              


Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val Lys Ser Val Asp 
    50                  55                  60                  


Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln 
65                  70                  75                  80  


Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His 
                85                  90                  95      


Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala 
            100                 105                 110         


Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr 
        115                 120                 125             


Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn 
    130                 135                 140                 


Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu 
145                 150                 155                 160 


Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp 
                165                 170                 175     


Cys Asp Ser Gly Thr Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser 
            180                 185                 190         


Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn 
        195                 200                 205             


Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg Pro 
    210                 215                 220                 


Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro 
225                 230                 235                 240 


Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr 
                245                 250                 255     


Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp 
            260                 265                 270         


Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr 
        275                 280                 285             


Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly 
    290                 295                 300                 


Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly 
305                 310                 315                 320 


Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys 
                325                 330                 335     


His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys Asp Val Pro 
            340                 345                 350         


Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Arg 
        355                 360                 365             


Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala 
    370                 375                 380                 


Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys 
385                 390                 395                 400 


Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys 
                405                 410                 415     


Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly Arg 
            420                 425                 430         


Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu 
        435                 440                 445             


Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp 
    450                 455                 460                 


Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu 
465                 470                 475                 480 


Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu 
                485                 490                 495     


Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala 
            500                 505                 510         


Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu 
        515                 520                 525             


Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val 
    530                 535                 540                 


Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln 
545                 550                 555                 560 


Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
                565                 570                 575     


Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly 
            580                 585                 590         


Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr 
        595                 600                 605             


Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
    610                 615                 620 


<210>  125
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  125

Gln Glu Ile His Ala Arg Phe Arg Arg Gly Ala Arg Ser Tyr Gln Val 
1               5                   10                  15      


Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser 
            20                  25                  30          


Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys 
        35                  40                  45              


Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val Lys Ser Val Asp 
    50                  55                  60                  


Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln 
65                  70                  75                  80  


Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His 
                85                  90                  95      


Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala 
            100                 105                 110         


Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr 
        115                 120                 125             


Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn 
    130                 135                 140                 


Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu 
145                 150                 155                 160 


Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp 
                165                 170                 175     


Cys Asp Ser Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr 
            180                 185                 190         


Arg Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp 
        195                 200                 205             


Asn Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser 
    210                 215                 220                 


Ala Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp 
225                 230                 235                 240 


Gly Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr 
                245                 250                 255     


Trp Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln 
            260                 265                 270         


Tyr Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile 
        275                 280                 285             


Ala Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser 
    290                 295                 300                 


Pro Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp 
305                 310                 315                 320 


Ile Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His 
                325                 330                 335     


Leu Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu 
            340                 345                 350         


Glu Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp 
        355                 360                 365             


Asp Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp 
    370                 375                 380                 


Ser Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu 
385                 390                 395                 400 


Pro Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser 
                405                 410                 415     


Gly Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu 
            420                 425                 430         


Lys Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln 
        435                 440                 445             


His Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp 
    450                 455                 460                 


Thr Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly 
465                 470                 475                 480 


Asp Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu 
                485                 490                 495     


Val Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro 
            500                 505                 510         


Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn 
        515                 520                 525             


Met Arg Pro 
    530     


<210>  126
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION ROTEIN

<400>  126

Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu 
1               5                   10                  15      


Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile 
            20                  25                  30          


Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys 
        35                  40                  45              


Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu 
    50                  55                  60                  


Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys 
65                  70                  75                  80  


Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr 
                85                  90                  95      


Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly 
            100                 105                 110         


Thr Asp Cys Asp Ser Gly Gln Glu Ile His Ala Arg Phe Arg Arg Gly 
        115                 120                 125             


Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile 
    130                 135                 140                 


Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg 
145                 150                 155                 160 


Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val 
                165                 170                 175     


Pro Val Lys Ser Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr 
            180                 185                 190         


Arg Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp 
        195                 200                 205             


Asn Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser 
    210                 215                 220                 


Ala Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp 
225                 230                 235                 240 


Gly Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr 
                245                 250                 255     


Trp Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln 
            260                 265                 270         


Tyr Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile 
        275                 280                 285             


Ala Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser 
    290                 295                 300                 


Pro Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp 
305                 310                 315                 320 


Ile Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His 
                325                 330                 335     


Leu Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu 
            340                 345                 350         


Glu Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp 
        355                 360                 365             


Asp Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp 
    370                 375                 380                 


Ser Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu 
385                 390                 395                 400 


Pro Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser 
                405                 410                 415     


Gly Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu 
            420                 425                 430         


Lys Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln 
        435                 440                 445             


His Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp 
    450                 455                 460                 


Thr Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly 
465                 470                 475                 480 


Asp Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu 
                485                 490                 495     


Val Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro 
            500                 505                 510         


Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn 
        515                 520                 525             


Met Arg Pro 
    530     


<210>  127
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUSION PROTEIN

<400>  127

Gln Glu Ile His Ala Arg Phe Arg Arg Gly Ala Arg Ser Tyr Gln Val 
1               5                   10                  15      


Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser 
            20                  25                  30          


Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys 
        35                  40                  45              


Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val Lys Ser Asn Ser 
    50                  55                  60                  


Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His Ser Leu 
65                  70                  75                  80  


Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile Leu Ile 
                85                  90                  95      


Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu 
            100                 105                 110         


Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp 
        115                 120                 125             


Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys Asp Val 
    130                 135                 140                 


Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe 
145                 150                 155                 160 


Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln 
                165                 170                 175     


Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu 
            180                 185                 190         


Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His 
        195                 200                 205             


Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly 
    210                 215                 220                 


Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val 
225                 230                 235                 240 


Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn 
                245                 250                 255     


Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln 
            260                 265                 270         


Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln 
        275                 280                 285             


Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu 
    290                 295                 300                 


Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg 
305                 310                 315                 320 


Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr 
                325                 330                 335     


Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro 
            340                 345                 350         


Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu 
        355                 360                 365             


Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp 
    370                 375                 380                 


Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val 
385                 390                 395                 400 


Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro Val Asp Pro 
                405                 410                 415     


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
            420                 425                 430         


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
        435                 440                 445             


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
    450                 455                 460                 


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
465                 470                 475                 480 


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
                485                 490                 495     


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
            500                 505                 510         


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
        515                 520                 525             


Asp Ser Gly 
    530     


<210>  128
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA variants

<400>  128

Gln Glu Ile His Ala Arg Phe Arg Arg Gly Ala Arg Ser Tyr Gln Val 
1               5                   10                  15      


Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser 
            20                  25                  30          


Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys 
        35                  40                  45              


Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val Lys Ser Cys Ser 
    50                  55                  60                  


Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu Tyr Phe 
65                  70                  75                  80  


Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys Cys Cys 
                85                  90                  95      


Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser Tyr 
            100                 105                 110         


Arg Gly Asn Trp Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp 
        115                 120                 125             


Gln Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg Pro Asp 
    130                 135                 140                 


Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp 
145                 150                 155                 160 


Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser 
                165                 170                 175     


Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp Cys 
            180                 185                 190         


Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr Glu 
        195                 200                 205             


Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly Lys 
    210                 215                 220                 


Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly Lys 
225                 230                 235                 240 


His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His 
                245                 250                 255     


Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys Asp Val Pro Ser 
            260                 265                 270         


Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Arg Ile 
        275                 280                 285             


Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala 
    290                 295                 300                 


Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly 
305                 310                 315                 320 


Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe 
                325                 330                 335     


Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr 
            340                 345                 350         


Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys 
        355                 360                 365             


Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile 
    370                 375                 380                 


Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser 
385                 390                 395                 400 


Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro 
                405                 410                 415     


Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu 
            420                 425                 430         


Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr 
        435                 440                 445             


Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr 
    450                 455                 460                 


Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala 
465                 470                 475                 480 


Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
                485                 490                 495     


Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu 
            500                 505                 510         


Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn 
        515                 520                 525             


Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
    530                 535                 



<210>  129
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  interdomain SK_EGFpolypeptide where EGF fused between beta and 
       gamma domain of SK

<400>  129

Ile Ala Gly Pro Glu Trp Leu Leu Asp Arg Pro Ser Val Asn Asn Ser 
1               5                   10                  15      


Gln Leu Val Val Ser Val Ala Gly Thr Val Glu Gly Thr Asn Gln Asp 
            20                  25                  30          


Ile Ser Leu Lys Phe Phe Glu Ile Asp Leu Thr Ser Arg Pro Ala His 
        35                  40                  45              


Gly Gly Lys Thr Glu Gln Gly Leu Ser Pro Lys Ser Lys Pro Phe Ala 
    50                  55                  60                  


Thr Asp Ser Gly Ala Met Ser His Lys Leu Glu Lys Ala Asp Leu Leu 
65                  70                  75                  80  


Lys Ala Ile Gln Glu Gln Leu Ile Ala Asn Val His Ser Asn Asp Asp 
                85                  90                  95      


Tyr Phe Glu Val Ile Asp Phe Ala Ser Asp Ala Thr Ile Thr Asp Arg 
            100                 105                 110         


Asn Gly Lys Val Tyr Phe Ala Asp Lys Asp Gly Ser Val Thr Leu Pro 
        115                 120                 125             


Thr Gln Pro Val Gln Glu Phe Leu Leu Ser Gly His Val Arg Val Arg 
    130                 135                 140                 


Pro Tyr Lys Glu Lys Pro Ile Gln Asn Gln Ala Lys Ser Val Asp Val 
145                 150                 155                 160 


Glu Tyr Thr Val Gln Phe Thr Pro Leu Asn Pro Asp Asp Asp Phe Arg 
                165                 170                 175     


Pro Gly Leu Lys Asp Thr Lys Leu Leu Lys Thr Leu Ala Ile Gly Asp 
            180                 185                 190         


Thr Ile Thr Ser Gln Glu Leu Leu Ala Gln Ala Gln Ser Ile Leu Asn 
        195                 200                 205             


Lys Asn His Pro Gly Tyr Thr Ile Tyr Glu Arg Asp Ser Ser Ile Val 
    210                 215                 220                 


Thr His Asp Asn Asp Ile Phe Arg Thr Ile Leu Pro Met Asp Gln Glu 
225                 230                 235                 240 


Phe Thr Tyr Arg Val Lys Asn Arg Glu Gln Ala Tyr Arg Ile Asn Lys 
                245                 250                 255     


Lys Ser Gly Leu Asn Glu Glu Ile Asn Asn Thr Asp Leu Ile Ser Glu 
            260                 265                 270         


Lys Tyr Tyr Val Leu Lys Lys Gly Glu Lys Pro Tyr Asp Pro Phe Asp 
        275                 280                 285             


Arg Ser His Leu Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln 
    290                 295                 300                 


Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly 
305                 310                 315                 320 


Phe Ala Pro Ile Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn 
                325                 330                 335     


Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys 
            340                 345                 350         


Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp 
        355                 360                 365             


Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn 
    370                 375                 380                 


Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala 
385                 390                 395                 400 


Arg His Ile Gly Thr Asp Cys Asp Ser Gly Val Asp Pro Cys Phe Arg 
                405                 410                 415     


Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu 
            420                 425                 430         


Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His Arg 
        435                 440                 445             


Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro 
    450                 455                 460                 


Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp 
465                 470                 475                 480 


Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys 
                485                 490                 495     


Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly 
            500                 505                 510         


Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser Gly 
        515                 520                 525             


<210>  130
<211>  136
<212>  PRT
<213>  Staphylococcus aureus

<400>  130

Ser Ser Ser Phe Asp Lys Gly Lys Tyr Lys Lys Gly Asp Asp Ala Ser 
1               5                   10                  15      


Tyr Phe Glu Pro Thr Gly Pro Tyr Leu Met Val Asn Val Thr Gly Val 
            20                  25                  30          


Asp Ser Lys Gly Asn Glu Leu Leu Ser Pro His Tyr Val Glu Phe Pro 
        35                  40                  45              


Ile Lys Pro Gly Thr Thr Leu Thr Lys Glu Lys Ile Glu Tyr Tyr Val 
    50                  55                  60                  


Glu Trp Ala Leu Asp Ala Thr Ala Tyr Lys Glu Phe Arg Val Val Glu 
65                  70                  75                  80  


Leu Asp Pro Ser Ala Lys Ile Glu Val Thr Tyr Tyr Asp Lys Asn Lys 
                85                  90                  95      


Lys Lys Glu Glu Thr Lys Ser Phe Pro Ile Thr Glu Lys Gly Phe Val 
            100                 105                 110         


Val Pro Asp Leu Ser Glu His Ile Lys Asn Pro Gly Phe Asn Leu Ile 
        115                 120                 125             


Thr Lys Val Val Ile Glu Lys Lys 
    130                 135     



